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An update of two randomized trials in previously untreated multiple myeloma comparing melphalan and prednisone versus three- and five-drug combinations: an Argentine Group for the Treatment of Acute Leukemia Study.

Author: CavagnaroF, CorradoC, HubermanA, LeinJ M, PalauM, PavlovskyS, SantarelliM T, SaslavskyJ, de Tezanos PintoM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A long-term follow-up study of two randomized trials found that melphalan and prednisone (MP) therapy was as effective as three- and five-drug combinations in treating multiple myeloma.
Paper Details　
Original Abstract of the Article :
An update of two consecutive randomized studies in previously untreated multiple myeloma was performed. The first study (10-M-73) began in 1973; 150 patients were treated with melphalan and prednisone (MP) or semustine, cyclophosphamide, and prednisone (MeCP). In a second randomized study (3-M-77), ...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.1988.6.5.769

データ提供：米国国立医学図書館（NLM）

Multiple Myeloma Treatment: A Comparative Study of Treatment Strategies

In the vast expanse of cancer research, multiple myeloma presents a formidable challenge. This study navigates the complex landscape of multiple myeloma treatments, comparing the effectiveness of different drug combinations. The authors, like archaeologists excavating ancient ruins, analyze the outcomes of two randomized clinical trials, meticulously comparing the effectiveness of various drug combinations. Their findings illuminate the effectiveness of various strategies and provide valuable insights for optimizing treatment approaches.

Navigating the Sands of Time: Long-Term Survival Outcomes

The study's findings suggest that the simpler combination of melphalan and prednisone (MP) is as effective as more complex drug regimens in achieving long-term survival in multiple myeloma patients. This finding holds significant implications for treatment choices, suggesting that a simpler and potentially less expensive approach can be equally effective. The authors note that these results are based on long-term follow-up, providing a comprehensive view of the effectiveness of different treatment strategies over time.

A Guiding Oasis: Optimizing Treatment for Multiple Myeloma

This research emphasizes the importance of considering both effectiveness and practicality when choosing a treatment approach for multiple myeloma. The study suggests that MP, with its simplicity and cost-effectiveness, is a viable and potentially advantageous option for initial therapy. This approach may be a valuable oasis in the desert of multiple myeloma treatment, offering hope for patients while optimizing resource allocation.

Dr. Camel's Conclusion

This study offers a valuable roadmap for navigating the complex landscape of multiple myeloma treatment. By comparing different treatment approaches and analyzing long-term outcomes, the research provides valuable insights for optimizing treatment strategies and maximizing patient outcomes. The findings emphasize the importance of considering both effectiveness and practicality in treatment choices, paving the way for a more efficient and compassionate approach to managing this challenging disease.

Date :
  1. Date Completed 1988-06-10
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

3284974

DOI: Digital Object Identifier

10.1200/JCO.1988.6.5.769

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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