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In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review.

Author: KośmiderLeon, OtrębaMichał

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Phenothiazines, a class of drugs traditionally used as antipsychotics, are being investigated for their potential anticancer properties. This review summarizes research on fluphenazine, perphenazine, and prochlorperazine, highlighting their antitumor activity against various human cancer cell lines. These drugs exhibit anticancer effects by influencing cell cycle, proliferation, and apoptosis. They may target drug efflux pumps and regulate specific pathways involved in cancer cell growth. Further research is needed to evaluate their safety and efficacy in animal models and clinical trials.
Paper Details　
Original Abstract of the Article :
Drug repositioning is an approach that could accelerate the clinical use of compounds in different diseases. The goal is to take advantage of the fact that approved drugs have been tested on humans and detailed information is available on their pharmacology, toxicity and formulation. It can signific...See full text at original site
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引用元：
https://doi.org/10.1002/jat.4046

データ提供：米国国立医学図書館（NLM）

Fluphenazine, Perphenazine, and Prochlorperazine: Potential Anticancer Agents

The field of drug repositioning is a fascinating area of research, seeking to repurpose existing drugs for new therapeutic applications. This study explores the potential anticancer activity of three phenothiazine derivatives: fluphenazine, perphenazine, and prochlorperazine. It's like searching for a hidden treasure in a vast desert, discovering new potential uses for well-established compounds.

In Vitro Anticancer Activity of Phenothiazines

The study reviewed numerous publications investigating the anticancer activity of these phenothiazines in vitro. The research found that these drugs exhibited anticancer activity against various human cancer cell lines. This is like finding a promising oasis in the desert, suggesting new avenues for treating cancer.

Mechanisms of Anticancer Activity

The study identified several potential mechanisms for the anticancer activity of these drugs, including effects on cell cycle, proliferation, and apoptosis. This is like unraveling the complex web of interactions within a desert ecosystem, uncovering the underlying mechanisms that drive the anticancer activity of these compounds.

Dr. Camel's Conclusion

This research opens up exciting possibilities for drug repositioning. The study highlights the potential of fluphenazine, perphenazine, and prochlorperazine as anticancer agents. While further research is needed to fully understand their therapeutic potential, this study is a reminder that the desert of medical knowledge is full of hidden treasures waiting to be discovered.

Date :
  1. Date Completed 2021-12-06
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

32852120

DOI: Digital Object Identifier

10.1002/jat.4046

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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