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Evaluation of 17 patients with COVID-19 pneumonia treated with anakinra according to HScore, SOFA, MuLBSTA, and Brescia-COVID respiratory severity scale (BCRSS) scoring systems.

Author: AkinciEsragul, AypakAdalet, BilirYeşim Aybar, ErdenAbdulsamet, GunerRahmet, IzdesSeval, KalemAyse Kaya, KarakasOzlem, KucuksahinOrhan, MutluNevzat Mehmet, OzdemirBahar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effectiveness and safety of anakinra, an IL-1 blocker, in treating COVID-19 patients at high risk of worsening. The results suggest that anakinra may be beneficial in reducing the need for oxygen supplementation and hospitalization, particularly in patients with comorbidities. However, further research is needed to confirm these findings and to determine the optimal use of anakinra in the management of COVID-19.
Paper Details　
Original Abstract of the Article :
COVID-19 pandemic has been affecting the whole world by increasing morbidity and mortality rates day by day. Treatment algorithms have been attempted as parallel to the increasing experience with COVID-19. In the pathogenesis of this virus pro-inflammatory cytokine storm has been called to have the ...See full text at original site
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引用元：
https://doi.org/10.1002/jmv.26473

データ提供：米国国立医学図書館（NLM）

Anakinra: A Potential Treatment for COVID-19 Pneumonia?

This research investigates the potential of anakinra, an interleukin-1 (IL-1) receptor antagonist, as a treatment for COVID-19 pneumonia. The study evaluated the use of anakinra in a cohort of patients with COVID-19 who were at high risk of worsening symptoms. The researchers assessed the patients using various scoring systems to measure disease severity and monitored outcomes such as mortality, oxygen requirements, and hospital discharge. The study found that anakinra appeared to improve outcomes in some patients but emphasized the need for further research.

Navigating the Storm: IL-1 Blockade and COVID-19

This research explores the potential of targeting IL-1, a pro-inflammatory cytokine that plays a role in the pathogenesis of COVID-19 pneumonia. Just as a camel navigates a sandstorm by seeking shelter, researchers are seeking ways to mitigate the inflammatory storm associated with COVID-19. The study's findings suggest that anakinra could offer a potential therapeutic strategy for some patients.

COVID-19: A Journey Towards Understanding and Treatment

This research highlights the ongoing search for effective treatments for COVID-19 pneumonia, a complex and evolving disease. The study underscores the importance of individualized care, considering the specific needs of each patient and the potential benefits and risks of different treatment options. The research encourages further investigation into the role of anakinra and other potential therapies for COVID-19.

Dr. Camel's Conclusion

This research investigates the potential of anakinra as a treatment for COVID-19 pneumonia. The study's findings suggest that anakinra may offer a potential therapeutic strategy for some patients, but further research is needed to fully understand its efficacy and safety.
Date :
  1. Date Completed 2021-03-08
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

32860431

DOI: Digital Object Identifier

10.1002/jmv.26473

Related Literature

Article Analysis
・Side Effects of anakinra
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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