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Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol.

Author: BrandonRebecca, DohertyGlenn, GriffithsDale, Harré HindmarshJennie, JiangYannan, Macaskill-SmithKerry, MerrimanTony R, MoffittAllan, MurphyRinki, Orr-WalkerBrandon, PaulRyan, SmallmanKate, YeuRui Qian

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates whether the glycemic response to vildagliptin (a dipeptidyl peptidase-4 inhibitor) and pioglitazone (a thiazolidinedione), common diabetes medications, varies based on ethnicity, gender, obesity, triglyceride levels, or genetic variations.
Paper Details　
Original Abstract of the Article :
There is emerging evidence for stratified glucose-lowering responses to certain oral medications for type 2 diabetes (T2D) by individual characteristics. The objective of this study was to test whether glycaemic response to representative treatments of dipeptidyl peptidase-4 inhibitors (vildagliptin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467516/

データ提供：米国国立医学図書館（NLM）

WORTH Study: Tailoring Diabetes Treatment to Individual Needs

This study, aptly named WORTH (Which One is Right Here), investigates the efficacy of vildagliptin and pioglitazone as add-on therapies for type 2 diabetes. Just like a camel caravan navigating diverse landscapes, individuals with type 2 diabetes respond differently to various medications. The study seeks to identify factors influencing these responses, including ethnicity, gender, baseline obesity, triglyceride levels, and genetic variations. The goal is to develop personalized treatment strategies for better glucose control in type 2 diabetes patients.

Personalized Diabetes Management: A Step Towards Precision Medicine

The WORTH study paves the way for personalized diabetes management, taking into account individual characteristics. This research aims to provide more tailored treatment approaches, akin to a skilled camel driver who adjusts their strategy based on the terrain and the caravan's needs.

Understanding Individual Differences for Better Diabetes Care

By considering individual characteristics, the WORTH study emphasizes the importance of personalized medicine in diabetes care. It's akin to providing the right type of water to a camel caravan in different desert regions, ensuring optimal hydration and a smooth journey.

Dr. Camel's Conclusion

The WORTH study highlights the importance of personalized medicine in diabetes care, acknowledging the unique needs of each individual. It's like offering a variety of succulent fruits and vegetables to a camel caravan traversing the desert, ensuring each camel gets the nutrients they need for optimal health and well-being.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

32873667

DOI: Digital Object Identifier

PMC7467516

Related Literature

Article Analysis
・Side Effects of pioglitazone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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