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The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs.

Author: AdunyahSamuel E, LeeEun-Sook, SonDeok-Soo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole, exert anticancer activities through various mechanisms, such as disruption of microtubule polymerization, induction of apoptosis, and cell cycle arrest. They show promise as adjuvants to conventional cancer therapies, offering a broad and safe spectrum of treatment.
Paper Details　
Original Abstract of the Article :
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both in human and veterinary medicin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458798/

データ提供：米国国立医学図書館（NLM）

Benzimidazole Anthelmintics: A New Frontier in Cancer Treatment

This study explores the potential of repurposing benzimidazole anthelmintics, commonly used to treat parasitic infections, for cancer treatment. The research delves into the diverse mechanisms by which these drugs exert their antitumor effects, including the disruption of microtubule polymerization and the induction of apoptosis.

Repurposing Drugs: A Promising Strategy

The study highlights the potential of repurposing existing drugs for new therapeutic applications. Benzimidazole anthelmintics have shown promising anticancer activities in both laboratory studies and clinical trials. These drugs offer a potential alternative or adjunct to conventional cancer therapies.

New Hope for Cancer Patients: Broader Treatment Options

The potential of benzimidazole anthelmintics to treat cancer is a significant development in the fight against this devastating disease. These drugs offer a broader spectrum of treatment options, potentially increasing the effectiveness of therapy and improving patient outcomes.

Dr.Camel's Conclusion

Just as a desert nomad repurposes materials found in the arid landscape, researchers are cleverly repurposing drugs to tackle new challenges. This study sheds light on the potential of benzimidazole anthelmintics as anticancer agents, offering a glimmer of hope for patients seeking new treatment options. This research highlights the need for continued exploration of repurposing drugs, expanding the horizons of therapeutic possibilities.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-08-01
Further Info :

Pubmed ID

32895616

DOI: Digital Object Identifier

PMC7458798

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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