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Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury.

Author: ChengChongjie, GuoZongduo, HeJunchi, HuangYike, HuangZhijian, JiangLi, JiangShaoqiu, LiuHan, LiuLiu, SunXiaochuan, WuJingchuan, ZhangZhaosi, ZhongJianjun, ZhouChao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bexarotene, a retinoid X receptor (RXR) agonist, can activate RXR/PPARγ heterodimers and promote axon regeneration and microglia/macrophages towards an anti-inflammatory state after traumatic brain injury (TBI) in mice. Bexarotene treatment increased brain-derived neurotrophic factor (BDNF) expression in microglia/macrophages, reduced the number of pro-inflammatory microglia/macrophages, increased the number of anti-inflammatory microglia/macrophages, and improved neurological scores and cognitive function in mice with TBI. These effects of bexarotene were partially abolished by the PPARγ antagonist T0070907.
Paper Details　
Original Abstract of the Article :
Traumatic brain injury (TBI) has been regarded as one of the leading cause of injury-related death and disability. White matter injury after TBI is characterized by axon damage and demyelination, resulting in neural network impairment and neurological deficit. Brain-derived neurotrophic factor (BDNF...See full text at original site
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引用元：
https://doi.org/10.1016/j.expneurol.2020.113462

データ提供：米国国立医学図書館（NLM）

Bexarotene: A New Path to Axon Regeneration After Traumatic Brain Injury

Traumatic brain injury (TBI) is a devastating condition that leaves many individuals with long-term disabilities. This study explores the potential of bexarotene, an agonist of retinoid X receptor (RXR), to promote axon regeneration after TBI. The researchers investigated the effects of bexarotene on brain-derived neurotrophic factor (BDNF) expression, microglia/macrophage activation, and axon sprouting in mice subjected to controlled cortical impact (CCI).

Bexarotene: A Bridge Across the Gap

The study found that bexarotene promoted axon regeneration after TBI, as evidenced by increased expression of growth-associated protein 43 (GAP43) and myelin basic protein (MBP), as well as increased biotinylated dextran amine (BDA)-positive axon sprouting. Bexarotene also increased microglia/macrophage-specific BDNF expression, shifted microglia/macrophages towards an anti-inflammatory state, and reduced pro-inflammatory cytokine secretion. These effects were partially abolished by the PPARγ antagonist T0070907.

A Potential for New Therapies

The study's findings suggest that bexarotene may offer a promising therapeutic strategy for promoting axon regeneration after TBI. The research provides valuable insights into the potential of bexarotene to enhance neurological recovery and improve functional outcomes in patients with TBI.

Dr.Camel's Conclusion

This study unveils the potential of bexarotene to promote axon regeneration after TBI. The findings suggest that bexarotene, by modulating BDNF expression and microglia/macrophage activation, can enhance neurological recovery and improve functional outcomes in patients with TBI. This research opens up a new path for exploring innovative therapies for TBI.

Date :
  1. Date Completed 2021-03-10
  2. Date Revised 2021-03-10
Further Info :

Pubmed ID

32916173

DOI: Digital Object Identifier

10.1016/j.expneurol.2020.113462

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Languages

English

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