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Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors.
Author: FujiokaYayoi, FujitaHidenori, FunabashiKaoru, HiraiHiroshi, ItoKenjiro, ItoKimihiro, ItoSatoru, MatsuoKenichi, MiuraAkihiro, OchiiwaHiroaki, OhsawaHirokazu, OtsukiSachie, SagaraTakeshi, SootomeHiroshi, YashiroMasakazu, YonekuraKazuhiko
Original Abstract of the Article :
FGFR signaling is deregulated in many human cancers, and FGFR is considered a valid target in FGFR-deregulated tumors. Here, we examine the preclinical profile of futibatinib (TAS-120; 1-[(3S)-[4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3, 4-d] pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-on...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1158/0008-5472.CAN-19-2568
データ提供:米国国立医学図書館(NLM)
Futibatinib: A Novel Inhibitor Targeting FGFR Signaling in Cancer
Cancer research is a complex and ever-evolving field, like a vast and ever-shifting desert landscape. This research delves into the potential of futibatinib, a novel irreversible inhibitor of fibroblast growth factor receptors (FGFRs), as a targeted therapy for FGFR-deregulated tumors. The study explored the preclinical profile of futibatinib, analyzing its selective inhibition of FGFRs and its antitumor activity in various cancer cell lines and models. It's like searching for a hidden oasis of therapeutic potential in the desert of cancer research.
Futibatinib: A Promising New Weapon in the Fight Against Cancer
This study provides compelling evidence for the potential of futibatinib as a targeted therapy for FGFR-driven cancers. The researchers found that futibatinib exhibited significant and selective antitumor activity in various preclinical models. It's like discovering a new and powerful weapon in the battle against a formidable foe.
The Desert of Cancer Research: A Constant Search for New Solutions
The desert of cancer research is a constant search for new and effective therapies. This study highlights the importance of exploring novel targets and developing innovative drugs that can precisely target specific pathways involved in cancer growth. It's a reminder to persevere in the quest for solutions, always seeking new oases of hope in the vast and challenging landscape of cancer research.
Dr.Camel's Conclusion
This research offers a glimmer of hope for patients with FGFR-driven cancers, providing a promising new therapeutic avenue for this challenging disease. It reinforces the need for continued research and development of targeted therapies, navigating the complex desert of cancer research with determination and innovation.
Date :
- Date Completed 2021-02-12
- Date Revised 2021-03-16
Further Info :
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