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Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial.

Author: , DanielsJane P, DoustAnn M, HewittCatherine A, HorneAndrew W, KoscielniakMagda, MiddletonLee J, SzubertWojciech, VincentKaty

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A multicentre, randomised, double-blind, placebo-controlled trial was conducted to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology. 306 women were randomly assigned to receive either gabapentin or matching placebo for 16 weeks. The study found that treatment with gabapentin did not result in significantly lower pain scores and was associated with higher rates of side-effects than placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chronic pelvic pain affects 2-24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic patholog...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527829/

データ提供：米国国立医学図書館（NLM）

Gabapentin for Chronic Pelvic Pain: A Desert of Uncertainties

The desert of chronic pelvic pain is a desolate and debilitating landscape, affecting millions of women worldwide. This study explores the potential of gabapentin, a medication commonly used for seizures and nerve pain, as a treatment for chronic pelvic pain. The authors conducted a large, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology.

Gabapentin: No Significant Benefit for Chronic Pelvic Pain

The results of the study indicate that gabapentin did not significantly reduce pain scores in women with chronic pelvic pain compared to placebo. Furthermore, the study found that gabapentin was associated with a higher rate of side effects, including dizziness, drowsiness, and visual disturbances. These findings suggest that gabapentin may not be an effective or safe treatment option for chronic pelvic pain.

Navigating the Desert of Chronic Pelvic Pain

As a desert wanderer, I know the importance of finding reliable sources of relief in the face of adversity. This study highlights the importance of careful consideration when evaluating potential treatments for chronic pelvic pain. The lack of significant benefit and increased risk of side effects associated with gabapentin for this condition emphasize the need for alternative treatment approaches.

Dr.Camel's Conclusion

This large, well-designed trial provides compelling evidence that gabapentin is not an effective treatment for chronic pelvic pain in women. The lack of efficacy and higher rate of side effects suggest that alternative treatment options should be considered for this debilitating condition. Further research is needed to identify safe and effective treatments for chronic pelvic pain, offering hope for those navigating this challenging desert of discomfort.

Date :
  1. Date Completed 2020-10-06
  2. Date Revised 2023-01-04
Further Info :

Pubmed ID

32979978

DOI: Digital Object Identifier

PMC7527829

Related Literature

Article Analysis
・Effective treatment of pelvic pain
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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