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Safety of palbociclib concurrent with palliative pelvic radiotherapy: discussion of a case of increased toxicity and brief review of literature.
Author: CzarnotaGregory J, DasguptaArchya, SahgalArjun, WarnerEllen
Original Abstract of the Article :
Several cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are indicated in the treatment of metastatic hormone receptor-positive (HR)/ human epidermal growth factor receptor 2 (HER2) negative breast cancer which includes palbociclib, ribociclib and abemaciclib. Pelvic radiation therapy (RT) is often i...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890927/
データ提供:米国国立医学図書館(NLM)
A Balancing Act: Palbociclib and Pelvic Radiotherapy
This study delves into the complex world of cancer treatment, focusing on the potential interactions between palbociclib, a drug used to treat breast cancer, and pelvic radiotherapy. This research examines the safety of using these treatments concurrently, highlighting the need for careful monitoring and management to minimize potential side effects.
The researchers present a case report of a patient who experienced increased toxicity after receiving palbociclib concurrently with pelvic radiotherapy. They highlight the potential for synergistic toxicity and discuss strategies for managing this risk.
Navigating the Risks of Combined Therapies
This case report serves as a reminder of the importance of careful consideration when combining cancer treatments. It emphasizes the need for close monitoring and communication between healthcare professionals to minimize the risk of complications.
Managing Cancer Treatment Side Effects
The findings of this study highlight the need for a multidisciplinary approach to cancer treatment, involving close collaboration between oncologists and radiation oncologists. This emphasizes the importance of thorough assessment of patient risk factors and the careful selection of treatment strategies to optimize outcomes and minimize side effects.
Dr.Camel's Conclusion
This study reminds us that even seemingly well-established cancer treatments can have unexpected interactions when combined. The careful consideration of potential side effects and the development of effective strategies for managing these risks are essential for improving patient outcomes. It's a reminder that the journey to conquer cancer is often fraught with challenges, requiring careful navigation and a deep understanding of the intricacies of disease and treatment.
Date :
- Date Completed 2021-10-08
- Date Revised 2021-10-08
Further Info :
Related Literature
English
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