Dermatologic Adverse Events Associated with Selective Fibroblast Growth Factor Receptor Inhibitors: Overview, Prevention, and Management Guidelines.

Author: Abou-AlfaGhassan, AnadkatMilan J, GuindonKathleen, KaffenbergerBenjamin, LacoutureMario E, LeventhalJonathan, SibaudVincent

Paper Details 
Original Abstract of the Article :
Fibroblast growth factor receptor (FGFR) tyrosine kinases, which are expressed on the cell membrane, are involved in a wide range of biological functions such as cell proliferation, survival, migration, and differentiation. The identification of FGFR fusions and other alterations in a wide range of ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873330/

データ提供:米国国立医学図書館(NLM)

Navigating the Skin's Desert: Dermatologic Adverse Events with FGFR Inhibitors

Fibroblast growth factor receptor (FGFR) inhibitors, a class of medications used to treat certain cancers, have shown great promise in the fight against disease. However, like a desert traveler encountering unexpected challenges, patients treated with FGFR inhibitors can experience dermatologic side effects. This review delves into the skin-related adverse events associated with these medications, aiming to provide oncologists with the knowledge they need to effectively manage these challenges. The authors explore the common and less common skin reactions associated with FGFR inhibitors, seeking to understand the mechanisms behind these reactions and develop strategies for prevention and management.

A Map of Skin Reactions: Navigating the Side Effects of FGFR Inhibitors

The review identifies a range of dermatologic adverse events associated with FGFR inhibitors, including nail changes, palmar-plantar erythrodysesthesia syndrome, stomatitis, and calciphylaxis. The authors emphasize the importance of early intervention and effective management to prevent premature discontinuation of treatment and maintain patient quality of life. The review provides practical guidelines for oncologists, enabling them to effectively navigate the potential challenges of skin reactions associated with FGFR inhibitors.

A Holistic Approach to Skin Care: Minimizing Discomfort and Maintaining Treatment

This review underscores the importance of a holistic approach to cancer care, considering not only the disease itself but also the potential side effects of treatment. By understanding the dermatologic adverse events associated with FGFR inhibitors, oncologists can provide patients with informed guidance and support, minimizing discomfort and maximizing treatment adherence. Just as a skilled guide helps a traveler navigate a challenging terrain, oncologists must be equipped to guide patients through the potential challenges of cancer treatment.

Dr.Camel's Conclusion

This review, a journey through the desert of dermatologic adverse events, highlights the importance of understanding the full spectrum of treatment effects. By being aware of the potential skin reactions associated with FGFR inhibitors, oncologists can provide patients with the best possible care, minimizing discomfort and maximizing treatment efficacy. As we continue to explore the vast landscape of cancer treatment, we must remain vigilant in our pursuit of safe and effective therapies that improve patient outcomes.

Date :
  1. Date Completed 2021-06-18
  2. Date Revised 2023-09-19
Further Info :

Pubmed ID

33021006

DOI: Digital Object Identifier

PMC7873330

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.