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Effect of prucalopride on sildenafil-induced inhibition of esophageal peristalsis in healthy adults.

Author: ChenChien-Lin, HungJui-Sheng, LeiWei-Yi, LiangShu-Wei, LiuTso-Tsai, OrrWilliam C, WongMing-Wun, YiChih-Hsun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Prucalopride, a 5-HT4 receptor agonist, enhances esophageal peristalsis, while sildenafil, a phosphodiesterase type 5 inhibitor, inhibits it. This study investigated whether prucalopride could augment esophageal peristalsis following sildenafil administration.
Paper Details　
Original Abstract of the Article :
Prucalopride, a high-affinity 5-hydroxytryptamine 4 receptor agonist, promotes esophageal peristalsis, while phosphodiesterase type 5 inhibitor sildenafil inhibits esophageal peristalsis. The present study was aimed to evaluate whether prucalopride would augment esophageal peristalsis subsequent to ...See full text at original site
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引用元：
https://doi.org/10.1111/jgh.15305

データ提供：米国国立医学図書館（NLM）

The Effect of Prucalopride on Sildenafil-Induced Inhibition of Esophageal Peristalsis

Dr. Camel here, your guide through the intricate world of gastrointestinal physiology! This study explores the interplay between two drugs, prucalopride and sildenafil, and their impact on esophageal peristalsis, the rhythmic contractions that move food through the esophagus. This research is like navigating a complex desert ecosystem, seeking to understand the delicate balance of forces that govern our digestive system.

Unveiling the Interplay of Drugs and Esophageal Peristalsis

The study investigates the effect of prucalopride, a drug that promotes esophageal peristalsis, on the inhibitory effects of sildenafil, a drug that can suppress esophageal peristalsis. This research is like exploring a hidden oasis in the vast desert of gastrointestinal physiology, seeking to understand the intricate interactions between different drugs and their impact on our digestive system.

Potential for Optimizing Treatment Strategies

The study provides valuable insights into the potential interactions between prucalopride and sildenafil, offering a foundation for optimizing treatment strategies for patients who use both medications. The research highlights the importance of considering the potential impact of drug interactions on gastrointestinal function. It's like discovering a new source of water in the desert, a potential solution for managing drug interactions and improving patient outcomes.

Dr.Camel's Conclusion

This study explores the complex interaction between prucalopride and sildenafil on esophageal peristalsis. The findings offer valuable insights for optimizing treatment strategies and managing potential drug interactions. It's like finding a new route through the desert of gastrointestinal research, a path towards a better understanding of drug interactions and improved patient care.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2021-11-01
Further Info :

Pubmed ID

33080085

DOI: Digital Object Identifier

10.1111/jgh.15305

Related Literature

Article Analysis
・Effects of prucalopride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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