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FGF21 Enhances Therapeutic Efficacy and Reduces Side Effects of Dexamethasone in Treatment of Rheumatoid Arthritis.

Author: GaoRong-Hui, JiangYuan-Yuan, LiDe-Shan, LiYan-Hua, MeiYu, SunXu, WangGuan-Ying, WangWen-Fei, WangYu-Jia, XiaoWei, XieYin-Zhuo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the efficacy of FGF21 combined with dexamethasone for the treatment of rheumatoid arthritis (RA) in mice. The study found that FGF21 combined with dexamethasone was more effective than either treatment alone and reduced the side effects of dexamethasone.
Paper Details　
Original Abstract of the Article :
In order to investigate efficacy of FGF21 combine dexamethasone (Dex) on rheumatoid arthritis (RA) meanwhile reduce side effects of dexamethasone. We used combination therapy (Dex 15 mg/kg + FGF21 0.25 mg/kg, Dex 15 mg/kg + FGF21 0.5 mg/kg or Dex 15 mg/kg + FGF21 1 mg/kg) and monotherapy (Dex 15 mg/...See full text at original site
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引用元：
https://doi.org/10.1007/s10753-020-01327-5

データ提供：米国国立医学図書館（NLM）

FGF21: A Potential Ally in the Treatment of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a debilitating autoimmune disease that affects millions worldwide. Finding effective treatments that minimize side effects remains a key challenge in the field. This study investigated the potential of combining FGF21 with dexamethasone, a common RA medication, to enhance therapeutic efficacy and reduce adverse events.

The researchers compared different combinations of FGF21 and dexamethasone in mice with RA. They found that FGF21 not only improved the effectiveness of dexamethasone in controlling RA symptoms but also mitigated the undesirable side effects of this medication. This is akin to finding a hidden spring in the desert, where a small dose of water can revitalize a weary traveler and quench their thirst.

A Synergistic Approach to RA Treatment

The study suggests that combining FGF21 with dexamethasone can be a powerful therapeutic strategy for RA, offering a more effective and well-tolerated treatment option. It's a promising step towards finding solutions that improve the lives of individuals living with RA, like finding a path through a vast and unforgiving desert.

Taking Charge of Your RA: A Holistic Approach

The findings emphasize the importance of a holistic approach to managing RA, considering both the physical and metabolic aspects of the disease. This study suggests that incorporating FGF21 into treatment plans might offer a way to improve RA outcomes and minimize side effects. It's a reminder that in the journey of managing RA, knowledge and understanding are our guiding stars.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the ongoing fight against rheumatoid arthritis. By combining FGF21 with dexamethasone, researchers have identified a potential strategy for improving RA treatment and minimizing side effects. It's a reminder that even in the face of adversity, there's always room for innovation and discovery.

Date :
  1. Date Completed 2021-10-07
  2. Date Revised 2021-10-07
Further Info :

Pubmed ID

33098521

DOI: Digital Object Identifier

10.1007/s10753-020-01327-5

SNS
PICO Info
in preparation
Languages

English

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