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Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis.
Author: AnseriniPaola, AreccoLuca, BonardiBenedetta, BruzzoneMarco, CeppiMarcello, Del MastroLucia, DemeestereIsabelle, GoldratOranite, LambertiniMatteo, MangiliGiorgia, MassarottiClaudia, SpinaciStefano
Original Abstract of the Article :
<b>Background:</b> The co-administration of letrozole during controlled ovarian stimulation (COS) with gonadotropins is used to limit the potentially harmful effects of a supra-physiological rise in estrogen levels on hormone-sensitive cancers. However, the efficacy and safety of adding letrozole t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575927/
データ提供：米国国立医学図書館（NLM）
Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis focuses on the use of [letrozole] in conjunction with [controlled ovarian stimulation (COS)] for [fertility preservation]. The researchers aim to assess the [efficacy and safety of letrozole co-administration] during COS, particularly for women with [hormone-sensitive cancers]. The study found that [letrozole co-administration did not negatively impact the efficacy of COS] and was associated with [significantly decreased peak estradiol levels].
Letrozole: A Safe and Effective Option for Fertility Preservation
This research provides reassuring data on the [use of letrozole in fertility preservation]. The study demonstrated that [letrozole co-administration did not negatively impact the number of mature oocytes retrieved] and [did not significantly affect other efficacy endpoints]. This suggests that [letrozole can be a safe and effective option] for [fertility preservation] in women with [hormone-sensitive cancers].
Balancing Fertility Preservation and Cancer Treatment
This research is significant for [women facing fertility challenges] due to [cancer treatment]. The study highlights the importance of [finding treatment options that balance fertility preservation with cancer treatment]. The findings suggest that [letrozole co-administration] may be a valuable tool for [minimizing the potential side effects] of [high estrogen levels] during [cancer treatment], while still allowing for [effective fertility preservation].
Dr.Camel's Conclusion
This research is a beacon of hope for women facing the difficult decision of balancing fertility preservation with cancer treatment. The findings suggest that letrozole can be a valuable tool for ensuring that women have the best possible chance of both overcoming cancer and preserving their fertility. This research is a testament to the ongoing efforts to improve the lives of women facing these challenging situations.
Date :
- Date Completed n.d.
- Date Revised 2020-10-30
Further Info :
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