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A phase I trial of temsirolimus and erlotinib in patients with refractory solid tumors.
Author: GovindanRamaswamy, LarsonSarah, LockhartA Craig, LuoJingqin, MorgenszternDaniel, ParkHaeseong, SureshRama, TanBenjamin, TrikalinosNikolaos A, Van TineBrian A, Wang-GillamAndrea, WaqarSaiama, WilliamsKerry
Original Abstract of the Article :
Resistance to treatment with inhibitors of mammalian target of rapamycin (mTOR) is partially mediated by activation of epidermal growth factor receptor (EGFR). We conducted a phase I study to determine the recommended phase II dose (RP2D) and dose-limiting toxicities (DLT) of temsirolimus (mTOR inhi...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/33159216
データ提供:米国国立医学図書館(NLM)
Targeting Cancer's Double Trouble: A New Approach to Fighting Solid Tumors
The world of cancer research is a vast desert, and we're constantly searching for new oases of hope. This study delves into the exciting realm of targeted therapy, focusing on a combination approach to combatting solid tumors. This research uses a combination of temsirolimus and erlotinib, a dynamic duo that targets two key players in cancer's growth: the mTOR pathway and the EGFR pathway. The researchers are like intrepid explorers, mapping out the ideal doses and potential side effects of this combination, aiming to find the sweet spot for effective treatment.
Finding the Right Dose: A Balancing Act
Like a skilled desert navigator, the researchers carefully calibrated the doses of temsirolimus and erlotinib, ultimately determining the recommended dose for future studies. This is a crucial step in ensuring the safety and effectiveness of this combination therapy. By meticulously navigating the landscape of potential side effects, they've paved the way for further exploration in the fight against solid tumors.
Double Trouble for Cancer: A New Weapon in the Arsenal
This research offers a promising approach to battling solid tumors. By targeting both the mTOR and EGFR pathways, we might be able to outsmart cancer's crafty tactics. This research opens the door for a new generation of cancer treatments that attack cancer's vulnerabilities on multiple fronts.
Dr. Camel's Conclusion
This study is a beacon of hope in the endless desert of cancer research. It demonstrates the potential of targeting multiple pathways simultaneously, like a skilled oasis builder creating a sustainable water source. This research adds a valuable tool to our arsenal in the fight against solid tumors, offering new hope for patients and pushing the boundaries of cancer treatment.
Date :
- Date Completed 2021-06-23
- Date Revised 2021-09-22
Further Info :
Related Literature
English
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