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Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics.

Author: ChanJerry Kok Yen, ChangKenneth Tou En, ChenJianzhu, ChenQingfeng, FanYong, HengShi Min, HerZhisheng, LaiFritz, LiuMin, TanSue Yee, TanWilson Wei Sheng, WangCheng-I, YongKylie Su Mei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Humanized mice, reconstituted with human fetal cells, can effectively mimic human-specific immune responses and pathological changes associated with immunotoxic biologics. The use of this model could potentially replace the need for clinical trials in assessing the immunotoxicity of biologics, mitigating risk for research participants and patients.
Paper Details　
Original Abstract of the Article :
Advancements in science enable researchers to constantly innovate and create novel biologics. However, the use of non-human animal models during the development of biologics impedes identification of precise <i>in vivo</i> interactions between the human immune system and treatments. Due to lack of t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604536/

データ提供：米国国立医学図書館（NLM）

Humanized Mice: A Tool for Predicting Immunotoxic Effects

This research explores the use of humanized mice, a model that allows for the study of human immune responses in a controlled environment. It’s like a desert oasis, providing a safe and controlled space to study the intricate workings of the human immune system. The study investigated the potential of humanized mice as a tool for predicting the immunotoxicity of human biologics.

Humanized Mice: A Window into the Human Immune System

The study demonstrates the value of humanized mice as a tool for studying human immune responses. It’s like a magnifying glass, offering a closer look at the complex interactions within the human immune system. The study highlights the potential of humanized mice to improve the safety and effectiveness of new therapies by allowing researchers to assess their impact on the human immune system.

Immunotoxicity: A Critical Consideration

The study emphasizes the critical importance of understanding the potential for immunotoxicity when developing new therapies. It’s like a camel crossing a desert filled with hidden dangers, requiring careful navigation and awareness of potential risks. This research encourages the use of humanized mice as a tool to identify and mitigate potential immunotoxic effects, improving the safety of new therapies.

Dr.Camel's Conclusion

This study highlights the potential of humanized mice as a valuable tool in preclinical research. It's like a wise desert guide, helping researchers navigate the complex landscape of the human immune system. By using this model to assess the potential for immunotoxicity, we can work toward developing safer and more effective therapies for a range of diseases.

Date :
  1. Date Completed 2021-04-30
  2. Date Revised 2021-04-30
Further Info :

Pubmed ID

33193321

DOI: Digital Object Identifier

PMC7604536

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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