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Sensitive determination of deferasirox in blood of patients with thalassemia using dispersive liquid-liquid microextraction based on solidification of floating organic drop followed by HPLC-UV.

Author: AkramipourReza, FattahiNazir, GolpayeganiMohammad Reza

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A new dispersive liquid-liquid microextraction method (DLLME-SFO) was developed for the determination of deferasirox in blood samples. It showed high sensitivity (detection limit of 0.06 µg/L) and good repeatability (3.8%) and reproducibility (5.7%). This simple and efficient method can be valuable for monitoring deferasirox levels in patients with thalassemia.
Paper Details　
Original Abstract of the Article :
Deferasirox is an oral iron chelator that has been on the market since 2005 and has been a suitable replacement for injectable chelators. It is important to check the amount of this drug in the blood of patients due to side effects. In this study, a new dispersive liquid-liquid microextraction based...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2020.113735

データ提供：米国国立医学図書館（NLM）

A Sensitive Method for Deferasirox Detection: DLLME-SFO

Keeping [iron overload] in check is crucial for individuals with [thalassemia]. [Deferasirox], an oral iron chelator, plays a vital role in managing this condition. This study focuses on developing a highly sensitive and efficient method for [deferasirox determination] in the blood of patients with [thalassemia] using a technique called [dispersive liquid-liquid microextraction based on solidification of floating organic drop (DLLME-SFO)].

DLLME-SFO: A Simple and Powerful Tool

The researchers skillfully combined [DLLME-SFO] with [high-performance liquid chromatography-ultraviolet detection (HPLC-UV)] to achieve a highly sensitive and precise analytical method. They demonstrated its ability to detect [deferasirox] in blood samples down to [0.06 µg L-1], with excellent repeatability and reproducibility. The method is also remarkably simple and environmentally friendly, making it a valuable tool for routine monitoring of [deferasirox] levels in patients with [thalassemia].

Monitoring Deferasirox Levels for Optimal Treatment

Accurate monitoring of [deferasirox] levels is essential for ensuring [optimal treatment] and minimizing potential side effects. This new method provides a powerful tool for clinicians to effectively manage [iron overload] in patients with [thalassemia]. It's like having a trusty compass in the desert of iron overload – a guide to help navigate the treatment landscape and ensure the best possible outcome.

Dr. Camel's Conclusion

DLLME-SFO offers a sensitive and efficient method for deferasirox determination in patients with thalassemia. This advancement in analytical techniques will significantly improve iron overload management and patient outcomes. It's like discovering a new oasis in the desert of iron overload, providing a reliable source of information for clinicians and their patients.

Date :
  1. Date Completed 2021-06-17
  2. Date Revised 2021-06-17
Further Info :

Pubmed ID

33202348

DOI: Digital Object Identifier

10.1016/j.jpba.2020.113735

Related Literature

Article Analysis
・Side Effects of deferasirox
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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