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Secukinumab and ustekinumab treatment in psoriatic arthritis: results of a direct comparison.

Author: BaudensGuy, Chary-ValckenaereIsabelle, ClaudepierrePascal, CohenNicolas, DeprezXavier, DieudePhilippe, FautrelBruno, FlachaireBenoît, FlipoRené-Marc, GervaisElisabeth, GuyotMarie-Hélène, HouvenagelEric, KyhengMaéva, LabadieCéline, LafforguePierre, LetarouillyJean-Guillaume, LoeuilleDamien, MarguerieLaurent, Miceli-RichardCorinne, NguyenChi Duc, PhamThao, PhilippePeggy, RichettePascal, RichezChristophe, SalmonJean-Hugues, SegaudNicolas, SellamJérémie, TubachFlorence

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Secukinumab had a higher persistence rate than ustekinumab in patients with Psoriatic arthritis (PsA). This difference was only found in association with methotrexate (MTX).
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To evaluate the characteristics of patients (pts) with PsA treated by ustekinumab (UST) or secukinumab (SEK) and to compare real-world persistence of UST and SEK in PsA. METHODS: In this retrospective, national, multicentre cohort study, pts with PsA (CASPAR criteria or diagnosis confir...See full text at original site
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引用元：
https://doi.org/10.1093/rheumatology/keaa710

データ提供：米国国立医学図書館（NLM）

Navigating the Shifting Sands of Psoriatic Arthritis Treatment

Psoriatic arthritis, a chronic inflammatory disease affecting the joints and skin, is like a relentless desert storm, causing pain, stiffness, and fatigue. This research, a guide through the complex landscape of treatment options, compares the real-world persistence of two biologic therapies, secukinumab and ustekinumab, in patients with psoriatic arthritis. The study sheds light on the effectiveness and tolerability of these therapies, providing valuable insights for clinicians and patients alike.

A Tale of Two Therapies

The study found that secukinumab demonstrated a higher persistence rate compared to ustekinumab, particularly when combined with methotrexate. While both therapies were effective in managing psoriatic arthritis, the study revealed that secukinumab may offer a more sustainable treatment option for some patients. This research, like a skilled desert navigator, provides valuable information for making informed decisions about treatment.

Finding Oasis in the Desert of Psoriatic Arthritis

This research offers valuable information for patients with psoriatic arthritis. It highlights the importance of working closely with a healthcare professional to determine the most appropriate treatment approach, considering individual needs and preferences. While no single treatment is perfect, this research helps shed light on the potential benefits and limitations of different therapies, guiding patients towards a more comfortable and fulfilling journey through the desert of psoriatic arthritis.

Dr. Camel's Conclusion

This research, like a caravan navigating a winding desert path, provides valuable insights into the complexities of treating psoriatic arthritis. It highlights the unique characteristics and effectiveness of different therapeutic approaches, empowering patients and clinicians to make informed decisions about treatment. It is a reminder that even in the challenging landscape of chronic diseases, there are options available to alleviate symptoms and improve quality of life.

Date :
  1. Date Completed 2021-08-19
  2. Date Revised 2021-08-19
Further Info :

Pubmed ID

33232465

DOI: Digital Object Identifier

10.1093/rheumatology/keaa710

Related Literature

Article Analysis
・Causes of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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