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Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil.

Author: CilurzoFelisa, CoscoDonato, CristianoMaria Chiara, FrestaMassimo, IannoneMichelangelo, MancusoAntonia, PaolinoDonatella, UrbanekKonrad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study designed a supramolecular colloidal carrier, i.e., a liquid crystal nanocarrier, for the selective delivery of active compounds into the pilosebaceous follicle. This nanocarrier showed mean sizes of ~80 nm, a good stability, a negative surface charge, and great safety properties.
Paper Details　
Original Abstract of the Article :
The topical administration of active compounds represents an advantageous strategy to reach the various skin components as well as its appendages. Pilosebaceous follicles are skin appendages originating in the deeper skin layers. They are very difficult to target, and hence higher active dosages are...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700400/

データ提供：米国国立医学図書館（NLM）

Targeting the Pilosebaceous Follicle with Liquid Crystal Nanocarriers

The pilosebaceous follicle, a tiny structure in the skin, is often difficult to target with topical medications. It's like trying to deliver water to a specific cactus in a vast desert. This study investigates the potential of liquid crystal nanocarriers for delivering minoxidil, a hair growth stimulant, to the pilosebaceous follicle.

Liquid Crystal Nanocarriers: A Targeted Delivery System

The researchers designed liquid crystal nanocarriers that showed good stability, safety, and the ability to penetrate the skin and deliver minoxidil to the pilosebaceous follicle. This approach offers a way to increase the effectiveness of topical treatments and reduce side effects. It's like finding a way to transport water directly to the root of a cactus, maximizing its hydration and promoting its growth.

Enhanced Effectiveness and Reduced Side Effects

The study showed that minoxidil-loaded liquid crystal nanocarriers were more effective in reaching the pilosebaceous follicle and delivering minoxidil, leading to improved biological response and reduced side effects. It's like finding a way to deliver water to the heart of a cactus without overwatering the surrounding desert landscape.

Dr.Camel's Conclusion

This research highlights the potential of liquid crystal nanocarriers for targeted delivery of active compounds to the pilosebaceous follicle. This approach offers a promising strategy for improving the effectiveness and safety of topical treatments for skin conditions. It's like finding a new way to irrigate a desert oasis, ensuring that vital nutrients reach their intended destination, promoting growth and well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-12-07
Further Info :

Pubmed ID

33266444

DOI: Digital Object Identifier

PMC7700400

Related Literature

Article Analysis
・Effects of minoxidil・Effects of minoxidil
SNS
PICO Info
in preparation
Languages

English

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