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Remarkable improvement of primary orthostatic tremor using perampanel.

Author: Grobe-EinslerMarcus, KautOliver

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A 53-year-old female with orthostatic tremor, refractory to previous treatments, experienced almost complete resolution of tremor after treatment with perampanel. This suggests a possible role of glutamate in the pathophysiology of orthostatic tremor.
Paper Details　
Original Abstract of the Article :
Management of primary orthostatic tremor (POT) remains challenging, and medication is often ineffective. We report the case of a 53-year-old female with orthostatic tremor for 6 years who was refractory to gabapentin, clonazepam, primidone and propranolol. After treatment with 4 mg/day perampanel, s...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650059/

データ提供：米国国立医学図書館（NLM）

Perampanel: A Potential Oasis in the Desert of Orthostatic Tremor

Orthostatic tremor, a neurological condition characterized by involuntary shaking when standing, can significantly impact quality of life. This research explores the potential of perampanel, an AMPA receptor antagonist, as a treatment option for primary orthostatic tremor (POT). The study reports a case of a patient with POT who experienced remarkable improvement after treatment with perampanel. This research suggests that perampanel may offer a promising treatment option for patients with POT who are refractory to conventional therapies.

Perampanel: A Potential Oasis in the Desert of Orthostatic Tremor

This study provides encouraging evidence for the potential efficacy of perampanel in treating primary orthostatic tremor (POT). The researchers report a case of a patient with POT who experienced significant improvement after treatment with perampanel, demonstrating the potential of this medication as a treatment option for this challenging condition. This research underscores the importance of exploring novel therapeutic approaches for neurological disorders, seeking solutions that can improve quality of life for patients.

Navigating the Desert of Neurological Treatment

This study highlights the importance of exploring new therapeutic approaches for neurological disorders like orthostatic tremor. The researchers' findings suggest that perampanel may offer a promising treatment option, particularly for patients who are refractory to conventional therapies. Just as camels navigate the vast and unpredictable desert, researchers must continue to explore innovative solutions for neurological disorders, seeking therapies that can provide relief and improve patient outcomes.

Dr.Camel's Conclusion

This study presents a compelling case for the potential efficacy of perampanel in treating primary orthostatic tremor. The findings suggest that perampanel may offer a promising treatment option for patients who are refractory to conventional therapies. Further research is needed to evaluate the long-term efficacy and safety of perampanel for POT.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-12-17
Further Info :

Pubmed ID

33324909

DOI: Digital Object Identifier

PMC7650059

SNS
PICO Info
in preparation
Languages

English

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