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Therapeutic Mechanisms of Ketamine.

Author: MihaljevićSlobodan, PavlovićMatko, ReinerKrešimir, ĆaćićMarko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Ketamine, previously known for anesthesia, has shown potential as an antidepressant. It is believed to reverse synaptic stress pathology by activating glutamate, leading to improved connectivity for days or weeks. While effective, ketamine can cause side effects like increased salivation and psychotomimetic effects. Esketamine nasal spray, a safer alternative, is now widely approved and provides consistent therapeutic benefit.
Paper Details　
Original Abstract of the Article :
Major depressive disorder is the greatest burden of developed countries in the context of morbidity caused by mental disorders. Until recent, ketamine has been mostly used for anesthesia, analgesia, sedation and treatment of chronic pain syndromes. However, unique pharmacodynamic properties of ketam...See full text at original site
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引用元：
https://doi.org/10.24869/psyd.2020.325

データ提供：米国国立医学図書館（NLM）

Ketamine: A New Hope in the Desert of Depression

Major depressive disorder (MDD), a challenging condition that can cast a long shadow over one's life, has been a persistent mystery in the desert of mental health research. This study explores the potential of ketamine, a medication traditionally used for anesthesia and pain management, as a novel treatment for MDD. The researchers delve into the unique pharmacodynamic properties of ketamine, highlighting its ability to rapidly reverse synaptic pathology associated with chronic stress. Ketamine's effects are thought to stem from its ability to activate glutamate receptors, which play a crucial role in synaptic plasticity and neuronal function. The study suggests that ketamine could potentially offer a new and effective approach to treating MDD, particularly in cases where traditional antidepressant medications have been ineffective. However, the study also acknowledges the need for careful monitoring due to ketamine's potential side effects.

A New Oasis in the Desert of Depression: Reversing Synaptic Pathology

This study offers hope for individuals struggling with MDD, demonstrating the potential of ketamine to rapidly reverse synaptic pathology associated with chronic stress. The findings suggest that ketamine could offer a new and effective treatment option, particularly for individuals who have not responded to traditional antidepressant medications. However, the study also underscores the importance of carefully monitoring patients receiving ketamine therapy due to its potential side effects.

A New Path to Recovery: Exploring the Potential of Ketamine

This study highlights the potential of ketamine as a novel treatment for MDD, offering hope for individuals who have not responded to traditional antidepressant medications. The research underscores the importance of exploring new and innovative approaches to treating mental health conditions, potentially opening up a new era of more effective and personalized therapies.

Dr.Camel's Conclusion

This study explores the therapeutic mechanisms of ketamine, highlighting its potential as a novel treatment option for major depressive disorder. The findings suggest that ketamine could offer a new and effective approach to treating MDD, particularly in cases where traditional antidepressant medications have been ineffective. However, the study also underscores the importance of carefully monitoring patients receiving ketamine therapy due to its potential side effects.
Date :
  1. Date Completed 2021-01-11
  2. Date Revised 2021-01-11
Further Info :

Pubmed ID

33370729

DOI: Digital Object Identifier

10.24869/psyd.2020.325

SNS
PICO Info
in preparation
Languages

English

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