Unveiling the basis of antiretroviral therapy-induced osteopenia: the effects of Dolutegravir, Darunavir and Atazanavir on osteogenesis.

Author: CazzanigaAlessandra, GalliMassimo, MaierJeanette, RusconiStefano, ScrimieriRoberta

Paper Details 
Original Abstract of the Article :
OBJECTIVES: Osteopenia is frequent in HIV-infected patients treated with antiretroviral therapy (ART) and has been linked to increased osteoclastogenesis. Little is known about the effects of ART on osteogenesis. DESIGN: We investigated the effect on human mesenchymal stem cells (hMSC) and osteobla...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/33394669

データ提供:米国国立医学図書館(NLM)

Antiretroviral Therapy and Bone Health: Investigating the Effects of Dolutegravir, Darunavir, and Atazanavir

The field of [HIV treatment] is constantly evolving, with the development of effective antiretroviral therapies (ART) leading to significant improvements in patient outcomes. However, the long-term effects of ART on bone health remain a concern. This study investigates the impact of three commonly used ART medications, [dolutegravir], [darunavir], and [atazanavir], on [osteogenesis], the process of bone formation. The research reveals that [atazanavir] and [dolutegravir] can impair [osteogenesis], highlighting the need for careful monitoring and management of bone health in patients receiving ART.

ART and Bone Health: A Delicate Balance

The findings of this study underscore the importance of considering the potential impact of ART on bone health. The study demonstrates that [atazanavir] and [dolutegravir] can negatively affect [osteogenesis], suggesting a need for strategies to mitigate these effects and preserve bone health in patients receiving ART. This research provides valuable insights into the complex interplay between ART and bone metabolism, emphasizing the importance of personalized treatment approaches and vigilant monitoring of bone health in individuals undergoing ART.

Protecting Bone Health in HIV Treatment

This research emphasizes the importance of proactive measures to protect bone health in patients receiving ART. The study's findings highlight the need for regular monitoring of bone density, early intervention for any signs of [osteopenia] or [osteoporosis], and the development of strategies to minimize the negative effects of certain ART medications on bone metabolism. It underscores the importance of collaborative care involving both [HIV specialists] and [bone health specialists] to optimize treatment outcomes and ensure the long-term well-being of patients with HIV.

Dr. Camel's Conclusion

Just as a camel needs a strong backbone to traverse the desert, patients with HIV need to maintain strong bones. This research reminds us that while ART offers hope for a healthier future, we must remain vigilant in protecting the health of our patients' bones. By understanding the potential impact of different ART medications, we can create treatment plans that safeguard their overall well-being.

Date :
  1. Date Completed 2021-04-06
  2. Date Revised 2023-09-21
Further Info :

Pubmed ID

33394669

DOI: Digital Object Identifier

00002030-202102020-00005

SNS
PICO Info
in preparation
Languages

English

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