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Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment.

Author: CreemersSara G, FeeldersRichard A, FranssenGaston J H, HoflandLeo J, de JongFrank H, de RijkeYolanda B, van KoetsveldPeter M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the in vitro effects of levoketoconazole, a pure enantiomer of ketoconazole, with racemic ketoconazole on adrenocortical and pituitary adenoma cells.
Paper Details　
Original Abstract of the Article :
Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing's syndrome. Levoketoconazole (COR-003), the pure 2S,4R enantiomer, is potentially more potent and safe compared to RK. We compared in vitro effects of levoketoconazole and RK on adrenocortical and pituitary adenom...See full text at original site
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引用元：
https://doi.org/10.1210/clinem/dgaa989

データ提供：米国国立医学図書館（NLM）

Levoketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment

This research explores the complex world of endocrine disorders, a territory as intricate as the shifting sands of a desert landscape. The researchers investigated the potential of levoketoconazole, a new steroidogenesis inhibitor, for treating Cushing's syndrome, a condition that can disrupt the body's delicate hormonal balance, much like a sandstorm that disrupts the tranquility of an oasis.

A New Oasis in the Desert of Cushing's Syndrome: Levoketoconazole Holds Promise

The study compared the effects of levoketoconazole to its racemic counterpart, ketoconazole, finding that the new enantiomer was potentially more potent and safe. This is like finding a new type of desert plant that offers greater benefits with fewer side effects. The researchers believe that levoketoconazole could be a valuable addition to the arsenal of treatments for Cushing's syndrome, offering a potentially more effective and well-tolerated solution for managing this challenging condition.

Navigating the Desert of Hormonal Imbalance: Finding a New Path to Wellness

This research highlights the ongoing search for better treatment options for endocrine disorders. The study provides valuable information about the potential benefits of levoketoconazole, offering hope for patients struggling with Cushing's syndrome. Like finding a reliable source of water in a desert landscape, this new drug could provide much-needed relief and support for those facing this complex and often debilitating condition.

Dr.Camel's Conclusion

This research underscores the importance of continuous innovation in the field of endocrinology. Just as a desert explorer must constantly adapt to changing conditions, researchers must strive to find new and improved ways to treat endocrine disorders, ensuring that patients have access to the best possible care and the highest quality of life.
Date :
  1. Date Completed 2021-09-21
  2. Date Revised 2021-09-21
Further Info :

Pubmed ID

33399817

DOI: Digital Object Identifier

10.1210/clinem/dgaa989

Related Literature

Article Analysis
・Effects of levoketoconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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