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Rifampicin impairs adipogenesis by suppressing NRF2-ARE activity in mice fed a high-fat diet.

Author: ChenYanyan, GaoTianchang, HouYongyong, LaiMiao, LiuZhiyuan, PiJingbo, RenSuping, WangZhendi, YinYuanyuan, ZhuXihe, ZuoZhuo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prolonged rifampicin treatment in mice on a high-fat diet reduced fat accumulation and adipogenic gene expression despite inducing insulin resistance. Rifampicin also inhibited adipogenesis in 3T3-L1 preadipocytes by interfering with the NRF2-ARE pathway.
Paper Details　
Original Abstract of the Article :
Prolonged treatment with rifampicin (RFP), a first-line antibacterial agent used in the treatment of drug-sensitive tuberculosis, may cause various side effects, including metabolic disorders. The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, also known as NRF2) plays an essential regulatory ...See full text at original site
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引用元：
https://doi.org/10.1016/j.taap.2020.115393

データ提供：米国国立医学図書館（NLM）

Rifampicin's Impact on Adipogenesis: A New Understanding of Its Side Effects

[Rifampicin], a widely used antibiotic, has been linked to [metabolic disorders]. This study investigates the effects of [rifampicin treatment] on [adipogenesis], the process of fat cell formation, in mice fed a high-fat diet. The researchers explored the mechanism by which rifampicin may impair adipogenesis, potentially contributing to metabolic disorders.

Rifampicin: A Double-Edged Sword?

The study found that [rifampicin treatment] in mice fed a high-fat diet led to [insulin resistance] and reduced fat accumulation, suggesting that rifampicin may interfere with adipogenesis. Further investigation revealed that rifampicin inhibits the activity of [NRF2-ARE], a signaling pathway involved in regulating adipogenesis. It's like finding a hidden trap in the desert, where a seemingly beneficial resource can have unexpected consequences.

A Deeper Understanding of Rifampicin's Impact

This research provides a deeper understanding of the potential side effects of [rifampicin treatment], particularly in individuals with [metabolic disorders]. It highlights the importance of considering the long-term effects of medications and exploring alternative therapies when appropriate. It's like understanding the interconnectedness of the desert ecosystem, where seemingly isolated elements can have profound impacts on the overall landscape.

Dr.Camel's Conclusion

This study underscores the importance of understanding the complex interplay between medications and metabolic processes. The findings suggest that [rifampicin treatment] may have unintended consequences for adipogenesis, highlighting the need for further research to optimize treatment strategies and minimize potential side effects.

Date :
  1. Date Completed 2021-05-11
  2. Date Revised 2021-05-11
Further Info :

Pubmed ID

33412187

DOI: Digital Object Identifier

10.1016/j.taap.2020.115393

Related Literature

Article Analysis
・Side Effects of rifampin
SNS
PICO Info
in preparation
Languages

English

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