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ESMO recommendations on the standard methods to detect RET fusions and mutations in daily practice and clinical research.
Author: AndréF, BelliC, CuriglianoG, DouillardJ-Y, DrilonA, EndrisV, GainorJ F, LacroixL, LadanyiM, NormannoN, Penault-LlorcaF, Reis-FilhoJ S, RepettoM, ScarpaA, ScoazecJ-Y, SubbiahV
Original Abstract of the Article :
Aberrant activation of RET is a critical driver of growth and proliferation in diverse solid tumours. Multikinase inhibitors (MKIs) showing anti-RET activities have been tested in RET-altered tumours with variable results. The low target specificity with consequent increase in side-effects and off-t...See full text at original site
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引用元:
https://doi.org/10.1016/j.annonc.2020.11.021
データ提供:米国国立医学図書館(NLM)
Precise Targeting of RET Alterations in Cancer
The aberrant activation of [RET] is a key driver of cancer growth and proliferation. This research focuses on the detection of RET fusions and mutations in various solid tumors, highlighting the importance of [precision medicine] in cancer treatment. The authors reviewed the available methods for detecting RET gene alterations and provided recommendations for routine clinical detection of targetable RET rearrangements and mutations. They emphasize the need for a rational approach to RET testing, especially in light of the development of new selective RET inhibitors like [pralsetinib] and [selpercatinib], which have shown promising results in clinical trials.
Precision Targeting: A New Frontier in Cancer Treatment
The study highlights the crucial role of accurate RET testing in guiding personalized cancer treatment. It underscores the significance of precision medicine in tailoring therapy to individual patients based on their specific genetic makeup.
Navigating the Sands of Cancer Treatment
This research provides a valuable guide for clinicians navigating the complex landscape of cancer treatment. By accurately identifying RET alterations, we can take a more targeted approach to therapy, potentially leading to better outcomes for patients.
Dr.Camel's Conclusion
This study, like a skilled camel scout, guides us through the vast desert of cancer research. By understanding the nuances of RET alterations, we can identify the most effective paths to treatment, ultimately leading to better outcomes for those battling this challenging disease.
Date :
- Date Completed 2023-11-13
- Date Revised 2023-11-13
Further Info :
Related Literature
English
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