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Comparison of the Pharmacokinetics of Generic Versus Branded Obeticholic Acid in a Chinese Population: Effects of Food and Sex.
Author: DingYanhua, HuYue, HuoDandan, LiCuiyun, LiXiaojiao, LiuLi, WangMeng, WuMin, XuZhongnan, YangDeming, ZhangHong, ZhengWenbo
Original Abstract of the Article :
The present study assessed the pharmacokinetics and bioequivalence of a single 10-mg dose of a generic and the branded formulation (Ocaliva) of obeticholic acid (OCA) in healthy Chinese subjects under fasting and fed conditions. The possible effects of food and sex on the pharmacokinetics of OCA and...See full text at original site
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引用元:
https://doi.org/10.1002/cpdd.905
データ提供:米国国立医学図書館(NLM)
Comparison of the Pharmacokinetics of Generic Versus Branded Obeticholic Acid in a Chinese Population: Effects of Food and Sex
Navigating the world of medications can be like traversing a vast desert, with different paths leading to different outcomes. This study explores the pharmacokinetics of a medication called obeticholic acid (OCA), comparing generic and branded formulations and investigating the influence of food and sex on its absorption and distribution. It's like studying the impact of different routes through a desert, considering the terrain, weather, and individual characteristics of the traveler.Bioequivalence of Generic and Branded Obeticholic Acid
This research found that the generic formulation of OCA is bioequivalent to the branded version, meaning that it delivers the same amount of medication to the body. It’s like finding two paths that lead to the same oasis, even though they traverse different terrain. This finding is reassuring for patients and healthcare providers, ensuring that switching between formulations can be done with confidence.Factors Influencing Medication Absorption and Distribution
This study highlights the importance of considering factors such as food intake and sex in understanding medication absorption and distribution. It’s like understanding the impact of different climates and terrain on a journey through the desert. Food and sex can alter the body's metabolic processes, influencing how medications are absorbed and metabolized. This research underscores the importance of individualized medicine, recognizing the diverse ways that medications can affect different individuals.Dr. Camel's Conclusion
This study provides valuable information for clinicians and researchers working to optimize medication use and ensure patient safety. It's like a map guiding us through the diverse landscape of medication pharmacokinetics, helping us understand the factors that influence drug absorption and distribution. This research underscores the importance of careful consideration of individual characteristics and environmental factors when prescribing and managing medications. Like a wise desert traveler, we need to be aware of the subtle nuances of our environment and adjust our actions accordingly.Date :
- Date Completed 2022-01-27
- Date Revised 2022-12-07
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