Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study.

Author: Fernández-ArjonaManuel, Fernández-PascualEsaú, Garrido-AbadPablo, Linares-EspinósEstefanía, ManfrediCeleste, Martínez-SalamancaJuan Ignacio, Senra-BravoIsabel, Varillas-DelgadoDavid

Paper Details 
Original Abstract of the Article :
Phosphodiesterase type 5 inhibitors (PDE5Is) are the first-line therapeutic option for erectile dysfunction (ED), while second-line therapy includes the alprostadil. Due to the different pharmacodynamic mechanism of PDE5Is and alprostadil, a synergistic action is conceivable when they are administer...See full text at original site
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引用元:
https://doi.org/10.1038/s41443-020-00400-9

データ提供:米国国立医学図書館(NLM)

A New Oasis in the Desert of Erectile Dysfunction: Combination Therapy

Erectile dysfunction (ED) is a common condition, affecting millions of men worldwide. It’s like a sandstorm in a man’s life, impacting self-esteem and relationships. This study explores the effectiveness of combining topical alprostadil with phosphodiesterase-5 inhibitors (PDE5Is) as a treatment option for patients who don’t respond to PDE5Is alone. The study uses the metaphor of a desert oasis to represent the potential of this combination therapy to provide relief for men with ED.

Exploring the Effectiveness of Combination Therapy: A Prospective Study

The authors conducted a prospective, two-arm, open-label, non-randomized study to evaluate the efficacy and safety of combination therapy in men with ED. This rigorous approach, like meticulously mapping a vast desert, aims to provide reliable data on the effectiveness of this treatment strategy. The results indicate that combination therapy is more effective than topical alprostadil alone in improving erectile function and overall satisfaction, offering a promising alternative for men who haven’t experienced success with PDE5Is alone.

A Promise of Improved Outcomes: A Beacon of Hope for Men with ED

This study offers a beacon of hope for men struggling with ED, suggesting that combination therapy may provide a more effective and satisfying treatment option. This research is a reminder that in the vast and often challenging landscape of men’s health, continuous innovation and research are essential to discover better ways to address common conditions and improve the quality of life for millions of men.

Dr.Camel's Conclusion

This study explores the potential of combination therapy for men with ED, suggesting that combining topical alprostadil with PDE5Is can lead to improved outcomes and greater satisfaction. The study is a valuable contribution to the ongoing research on ED, highlighting the importance of exploring new treatment strategies to provide effective solutions for men facing this common condition.

Date :
  1. Date Completed 2022-03-31
  2. Date Revised 2023-01-29
Further Info :

Pubmed ID

33483603

DOI: Digital Object Identifier

10.1038/s41443-020-00400-9

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Languages

English

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