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Impact of cold and flu medication on obstructive sleep apnoea and its underlying traits: A pilot randomized controlled trial.

Author: AzarbarzinAli, CalianeseNicole, HessLauren, KimSang-Wook, SandsScott, Taranto-MontemurroLuigi, VenaDaniel, WellmanAndrew, WhiteDavid P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to evaluate the effects of a combination of pseudoephedrine, an alpha-1 adrenergic agonist, and diphenhydramine, an antihistaminic-antimuscarinic, on obstructive sleep apnea (OSA). The combination therapy may improve genioglossus muscle activity during sleep and potentially offer a novel treatment option for OSA.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND AND OBJECTIVE">Animal studies indicate that alpha-1 adrenergic receptor agonists and antimuscarinic agents improve genioglossus muscle activity during sleep and may be candidates for the pharmacological treatment of OSA. On the other hand, noradrenergic stimulants may be wake-promo...See full text at original site
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引用元：
https://doi.org/10.1111/resp.14009

データ提供：米国国立医学図書館（NLM）

Cold and Flu Medications: Potential Impact on Obstructive Sleep Apnea

The field of [Sleep Medicine] is constantly seeking to understand the factors that influence sleep disorders, including [obstructive sleep apnea (OSA)]. This study investigates the [potential impact of cold and flu medications] on OSA severity and its underlying traits. The researchers conducted a [pilot randomized controlled trial] to examine the effects of a combination of [pseudoephedrine (an alpha-1 adrenergic agonist)] and [diphenhydramine (an antihistaminic-antimuscarinic)] on OSA symptoms and associated physiological parameters. The study's findings offer insights into the potential role of [pharmacological interventions] in managing OSA and its underlying mechanisms.

Navigating the Complexities of OSA Treatment

This study sheds light on the potential for [cold and flu medications] to influence OSA severity and its underlying traits. The findings suggest that [certain medications] may have [both positive and negative effects] on OSA symptoms, highlighting the importance of [carefully considering medication use] in patients with this condition. This research provides valuable information for [optimizing OSA treatment] and [minimizing potential medication-related side effects].

A Reminder of Medication Interactions

This study serves as a reminder of the importance of [considering medication interactions] in patients with OSA. Just as a camel needs to navigate the desert with a keen awareness of its surroundings, healthcare providers need to carefully consider the potential impact of medications on OSA symptoms and associated physiological parameters.

Dr.Camel's Conclusion

This pilot randomized controlled trial provides valuable insights into the potential impact of cold and flu medications on OSA. The study's findings highlight the importance of considering medication interactions in patients with OSA and underscore the need for further research to understand the complex interplay between medications and sleep disorders.

Date :
  1. Date Completed 2021-10-05
  2. Date Revised 2021-10-05
Further Info :

Pubmed ID

33491327

DOI: Digital Object Identifier

10.1111/resp.14009

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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