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Alkaline-phosphatase triggered self-assemblies enhances the anti-inflammatory property of methylprednisolone in spinal cord injury.

Author: QuDongbin, YuHaotao, ZhangPing, ZhongZhihong, ZhouWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A novel self-assembly system of oligopeptides was developed to locally deliver methylprednisolone sodium phosphate (MP) for spinal cord injury (SCI). This system, triggered by alkaline phosphatase (ALP), physically entrapped MP and released it in a sustained manner. In vivo studies showed that MP delivery using this system significantly reduced pro-inflammatory cytokines and improved histological outcomes in SCI.
Paper Details　
Original Abstract of the Article :
Methylprednisolone sodium phosphate (MP) is an anti-inflammatory corticosteroid which is used in the treatment of spinal cord injury (SCI), however the overdose of MP has toxic effects Therefore it is prerequisite to develop novel approaches to overcome the side effects of MP and enhance its efficac...See full text at original site
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引用元：
https://doi.org/10.1177/2280800020978505

データ提供：米国国立医学図書館（NLM）

Harnessing the Power of Self-Assembly for Spinal Cord Injury Treatment

[Spinal cord injury (SCI)] presents a formidable challenge in [medicine], often leading to debilitating consequences. This study investigates the potential of a novel [self-assembly system] to enhance the efficacy of [methylprednisolone (MP)] in treating [SCI]. The researchers developed an [alkaline phosphatase (ALP)-triggered self-assembly system] to deliver [MP] locally and sustainably, aiming to minimize side effects and maximize therapeutic benefits.

A Promising Approach to Spinal Cord Injury Treatment

The study demonstrates the effectiveness of the [ALP-triggered self-assembly system] in delivering [MP] locally and sustainably. The researchers found that the [hydrogel] formed by the [oligopeptides] effectively entrapped [MP] and released it in a controlled manner, potentially leading to improved therapeutic outcomes. The observed reduction in [pro-inflammatory cytokines] and improvement in [histological analysis] suggest that the [MP+1P] formulation holds significant promise for treating [SCI].

A New Frontier in Spinal Cord Injury Management

This research opens exciting new avenues for the treatment of [SCI]. The development of [ALP-triggered self-assembly systems] provides a promising approach to deliver [MP] locally and sustainably, potentially minimizing side effects and enhancing therapeutic benefits. The findings emphasize the importance of continued research in this field to advance our understanding and treatment options for [SCI].

Dr. Camel's Conclusion

This study is like a desert oasis, offering a glimmer of hope for individuals facing the challenges of [SCI]. The innovative approach of using [self-assembly systems] to deliver [MP] could significantly improve treatment outcomes and alleviate the burden of this debilitating condition. The quest for effective solutions for [SCI] continues, driven by the relentless pursuit of better outcomes for our patients.

Date :
  1. Date Completed 2021-10-19
  2. Date Revised 2021-10-19
Further Info :

Pubmed ID

33535875

DOI: Digital Object Identifier

10.1177/2280800020978505

Related Literature

Article Analysis
・Side Effects of sodium phosphate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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