Paper Details

  1. Home
  2. Paper Details

Higher plasma drug levels in elderly people living with HIV treated with darunavir.

Author: AnderssonLars-Magnus, EdénArvid, EriksenJaran, GisslénMagnus, MellgrenÅsa, NilssonStaffan, ThalmeAnders, TreutigerCarl Johan, TyrbergErika

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared plasma drug levels of ART, PDDIs, and side-effects in PLHIV aged ≥ 65 years of age with controls ≤ 49 years of age.
Paper Details　
Original Abstract of the Article :
The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged ≥ 65 years of age are scarce....See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861408/

データ提供：米国国立医学図書館（NLM）

Higher Plasma Drug Levels in Elderly People Living with HIV Treated with Darunavir

The study delves into the vast desert of HIV treatment, focusing on the unique challenges faced by elderly patients. Like a caravan navigating a treacherous landscape, these individuals often face a multitude of health issues and take numerous medications, increasing the risk of drug interactions. This research explores the pharmacokinetics of darunavir, a key antiretroviral drug, in elderly people living with HIV-1, a group often overlooked in clinical research.

The findings suggest that elderly HIV patients exhibit higher plasma levels of darunavir compared to younger counterparts. This observation underscores the importance of individualized medication adjustments based on age and other factors.

Age Matters: Personalized Treatment is Key

This research sheds light on the need for tailored treatment approaches for elderly patients with HIV. It highlights the importance of monitoring drug levels and making necessary adjustments to ensure safety and efficacy. This is akin to adjusting the speed and direction of a caravan based on the terrain and conditions.

Navigating the Shifting Sands of HIV Treatment

This study is a beacon in the desert of HIV research, illuminating the need for personalized care for elderly patients. It reminds us that even in a seemingly well-mapped landscape, there are always new challenges and opportunities for improvement. As Dr. Camel, I am encouraged by this research and hope it inspires further investigations into the unique needs of this vulnerable population.

Date :
  1. Date Completed 2021-07-23
  2. Date Revised 2021-07-23
Further Info :

Pubmed ID

33539440

DOI: Digital Object Identifier

PMC7861408

Related Literature

Article Analysis
・Side Effects of darunavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.