Paper Details

  1. Home
  2. Paper Details

Differences in levetiracetam and perampanel treatment-related irritability in patients with epilepsy.

Author: HasegawaNaoya, TohyamaJun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that levetiracetam (LEV) and perampanel (PER) caused irritability in different groups of patients with epilepsy. LEV-related irritability was associated with temporal focal epileptic discharge on EEG and decreased with higher LEV dosages. PER-related irritability was associated with nontemporal focal epileptic discharge on EEG and a psychiatric comorbidity of irritability.
Paper Details　
Original Abstract of the Article :
PURPOSE: The present study evaluated whether patients with epilepsy who received both levetiracetam (LEV) and perampanel (PER) therapy showed side effects of irritability. The study also examined the relationship between patient characteristics and irritability when it occurred as a side effect. ME...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.yebeh.2020.107644

データ提供：米国国立医学図書館（NLM）

Irritability in Epilepsy: Unveiling the Mystery of Levetiracetam and Perampanel

This study delves into the world of epilepsy, a neurological condition characterized by seizures. The researchers focused on two medications commonly used to treat epilepsy, levetiracetam (LEV) and perampanel (PER). Their primary concern was to understand whether these medications could induce irritability as a side effect in patients with epilepsy. To gain insight, they meticulously examined the medical records of patients who were treated with both LEV and PER, analyzing the occurrence of irritability and its relationship with various patient characteristics.

Individualized Responses: A Tale of Two Drugs

The researchers found that LEV and PER caused irritability in different patient groups. Specifically, LEV-related irritability was associated with temporal focal epileptic discharge, while PER-related irritability was linked to psychiatric comorbidity of irritability and nontemporal focal epileptic discharge. Furthermore, LEV-related irritability seemed to decrease with higher dosages of LEV, while PER-related irritability persisted even at high dosages.

Navigating the Side Effects: A Personalized Approach

This research emphasizes the importance of carefully considering the potential for irritability as a side effect when prescribing LEV and PER to patients with epilepsy. The study suggests that tailoring medication choices and dosages to individual patient characteristics could help minimize the occurrence of this side effect. It's like navigating a desert – understanding the terrain and the different types of sand dunes can guide you towards a smoother journey.

Dr.Camel's Conclusion

The world of epilepsy treatment is a vast, swirling sandstorm of medications and side effects. LEV and PER, like two different species of desert flora, can cause irritability in different ways. Understanding these nuances is crucial for minimizing the discomfort and maximizing the effectiveness of treatment.

Date :
  1. Date Completed 2021-04-20
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

33549477

DOI: Digital Object Identifier

10.1016/j.yebeh.2020.107644

Related Literature

Article Analysis
・Side Effects of perampanel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.