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The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib.
Author: ArrateM Pia, ChildressMerrida A, FerrellP Brent, FischerMelissa A, GorskaAgnieszka E, JenkinsMatthew T, MoyoTamara K, RamseyHaley E, SavonaMichael R, SmithBrianna N, SunthankarKathryn I, VillaumeMatthew T
Original Abstract of the Article :
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome characterized by monocytic proliferation in the presence of dysplastic bone marrow changes, inflammatory symptoms, and propensity for transformation to acute myeloid leukemia (AML), with...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33617893
データ提供：米国国立医学図書館（NLM）
Targeting PI3K-δ in Chronic Myelomonocytic Leukemia: A New Frontier in Cancer Treatment
The world of oncology is often a quest for new weapons in the fight against cancer. Chronic myelomonocytic leukemia (CMML), a complex hematological malignancy, presents a particularly challenging landscape. This study explores the potential of targeting PI3K-δ, a signaling protein involved in cell growth and survival, as a treatment strategy for CMML. It's like discovering a hidden vulnerability in the armor of cancer, opening up new avenues for therapeutic intervention.
A Novel Approach: Targeting a Key Signaling Pathway
The study investigated the role of PI3K-δ in CMML, revealing its predominant expression in monocytic cells. This finding suggests that targeting PI3K-δ could be a promising approach to selectively inhibiting the growth of leukemic cells. It's like identifying a specific weakness in a fortress, allowing us to focus our attack on the most vulnerable point.
A Synergistic Approach: Combining PI3K-δ and JAK1/2 Inhibition
The study evaluated the efficacy of umbralisib, a PI3K-δ inhibitor, in combination with ruxolitinib, a JAK1/2 inhibitor, in treating CMML. The findings indicated that this combination treatment synergistically inhibited cell viability and clonogenicity, suggesting a potentially powerful approach to combat CMML. It's like combining the power of a well-aimed arrow with the force of a powerful spear, creating a devastating attack on the cancer cells.
Dr. Camel's Conclusion
This study offers a promising lead in the search for effective treatments for CMML. The findings suggest that targeting PI3K-δ, in combination with other therapeutic strategies, could be a valuable weapon in the fight against this challenging disease. It's a journey of discovery, akin to a camel navigating a vast and unknown desert, where every new finding brings us closer to a cure.
Date :
- Date Completed 2021-10-12
- Date Revised 2022-07-16
Further Info :
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