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A Genome-Wide Association Study of Nausea Incidence in Varenicline-Treated Cigarette Smokers.

Author: ChenowethMeghan J, KnightJo, LermanCaryn, TyndaleRachel F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Varenicline is an effective smoking cessation treatment, but long-term cessation rates are less than 25%. Nausea, the most common side effect of varenicline, affects approximately 28% of patients, is most common at the start of treatment, and can reduce cessation success. Genetic variation influences treatment response, but genetic contributors to individual differences in side effects are less understood.
Paper Details　
Original Abstract of the Article :
Varenicline is the most efficacious smoking cessation treatment; however, long-term cessation rates tend to be <25%. Nausea, the most common side effect of varenicline, observed in ~28% of individuals treated, peaks early following treatment initiation and reduces cessation success. Genetic variatio...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403240/

データ提供：米国国立医学図書館（NLM）

Quitting Smoking: The Role of Genetics and Nausea

This study delves into the fascinating world of smoking cessation, exploring the genetic and pharmacological factors that influence success rates. Varenicline, a medication known for its effectiveness in helping smokers quit, has a significant side effect: nausea. This study investigates the genetic basis for this side effect, attempting to understand why some individuals experience nausea while others do not. This knowledge can be used to personalize smoking cessation treatments, tailoring them to individual genetic profiles, potentially improving treatment outcomes.

Nausea: A Barrier to Smoking Cessation

Nausea is a common side effect of varenicline, a medication used to help people quit smoking. It can significantly affect an individual's ability to tolerate the medication, leading to reduced treatment adherence and ultimately impacting their chances of successfully quitting. This study highlights the need to understand the genetic factors that contribute to nausea, so that strategies can be developed to minimize this side effect.

Personalized Smoking Cessation: The Future of Quitting

The genetic component of medication response is a growing area of research, with promising implications for personalized medicine. This study highlights the potential to tailor smoking cessation treatments based on individual genetic profiles, minimizing side effects like nausea and improving treatment success. Imagine a future where personalized medications help smokers quit without the struggle of side effects. It's a future we can strive for, guided by research like this.

Dr.Camel's Conclusion

This research sheds light on the intricate interplay between genetics, medication response, and the success of smoking cessation treatments. By understanding the genetic basis for individual differences in side effects, we can move towards personalized medicine approaches that optimize treatment outcomes. Just as the desert provides a unique environment for diverse species, our genes influence our individual responses to medication, making personalized medicine a promising avenue for improving health outcomes.
Date :
  1. Date Completed 2021-11-24
  2. Date Revised 2022-03-14
Further Info :

Pubmed ID

33713409

DOI: Digital Object Identifier

PMC8403240

Related Literature

Article Analysis
・Side Effects of varenicline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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