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Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.

Author: AbumiyaMaiko, KameokaYoshihiro, MiuraMasatomo, TakahashiNaoto, TakahashiSaori, YoshiokaTomoko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bosutinib, a tyrosine kinase inhibitor, increased serum creatinine levels in patients, particularly those with the SLC22A2 808G/G genotype. The increase in creatinine was associated with bosutinib concentration and was mediated by organic cation transporter 2 (OCT2). Regular monitoring of serum creatinine is essential to avoid progression to severe renal dysfunction.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to investigate the effects of SLC22A2 808G&gt;T polymorphism and trough concentrations (C<sub>0</sub>) of bosutinib on serum creatinine in 28 patients taking bosutinib. At 1, 3, 6, 12, 24, and 36&#160;months after administration, analysis of bosutinib C<sub>0</sub> and ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973796/

データ提供：米国国立医学図書館（NLM）

Bosutinib and Renal Function: Understanding the Link

Bosutinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia, can sometimes impact renal function. This study examines the effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine levels in patients receiving bosutinib therapy.

SLC22A2 808G>T Polymorphism: A Potential Modifier of Renal Effects

The researchers discovered that SLC22A2 808G>T polymorphism, like a desert sandstorm, can influence the relationship between bosutinib concentration and serum creatinine levels. This finding highlights the importance of personalized medicine in optimizing treatment strategies.

Monitoring Renal Function During Bosutinib Therapy

This study emphasizes the need for careful monitoring of renal function in patients receiving bosutinib therapy. It's like a desert traveler keeping a watchful eye on their water supply, ensuring a safe and healthy journey.

Dr.Camel's Conclusion

This study sheds light on the complex relationship between bosutinib, SLC22A2 808G>T polymorphism, and renal function. It's like a desert expedition, revealing the hidden nuances of a challenging terrain.
Date :
  1. Date Completed 2021-10-11
  2. Date Revised 2021-10-11
Further Info :

Pubmed ID

33737618

DOI: Digital Object Identifier

PMC7973796

Related Literature

Article Analysis
・Effects of bosutinib
SNS
PICO Info
in preparation
Languages

English

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