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Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.

Author: BrennerDarren M, RaoSatish S C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Polyethylene glycol (PEG) and senna are recommended as first-line laxatives for chronic constipation, based on good evidence. Fiber supplements, fruits, stimulant laxatives, and magnesium-based products are also supported by moderate evidence. More research is needed on other OTC constipation treatments.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Constipation is commonly treated with over-the-counter (OTC) products whose efficacy and safety remain unclear. We performed a systematic review of OTC therapies for chronic constipation and provide evidence-based recommendations. METHODS: We searched PubMed and Embase for randomized ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191753/

データ提供：米国国立医学図書館（NLM）

Chronic Constipation: Navigating the OTC Landscape

Constipation, a common gastrointestinal ailment, can significantly impact quality of life. This study examines the efficacy and safety of over-the-counter (OTC) therapies for chronic constipation, offering evidence-based recommendations for navigating this complex condition.

The researchers conducted a systematic review of randomized controlled trials that evaluated OTC treatments for chronic constipation. They assessed the strength of evidence for various therapeutic categories, including osmotic laxatives, stimulant laxatives, fiber supplements, and other natural remedies.

The review found good evidence for the effectiveness of polyethylene glycol (PEG) and senna as first-line laxatives. Moderate evidence supported the use of psyllium, magnesium salts, and fruit-based laxatives. However, evidence for other treatments, such as polydextrose and inulin, was insufficient.

Finding Relief: A Guide to Choosing the Right OTC Remedy

This study provides valuable guidance for individuals seeking relief from chronic constipation. It offers evidence-based recommendations for choosing OTC treatments, highlighting the effectiveness of PEG and senna as first-line options. It's like a map in the desert, leading you towards a safe and effective path to relief.

Navigating Constipation with Confidence

This research underscores the importance of choosing evidence-based OTC therapies for chronic constipation. It encourages individuals to consult with healthcare professionals to determine the best treatment options for their individual needs.

Dr.Camel's Conclusion

This study provides a comprehensive overview of the efficacy and safety of OTC therapies for chronic constipation. It offers valuable insights for navigating the diverse landscape of treatment options, encouraging informed decision-making based on scientific evidence.

Date :
  1. Date Completed 2021-06-30
  2. Date Revised 2023-07-18
Further Info :

Pubmed ID

33767108

DOI: Digital Object Identifier

PMC8191753

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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