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Electrospun poly(lactic acid) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) nanofibers for the controlled release of cilostazol.

Author: AntunesLidiane Rodrigues, BreitenbachGabriela Lauer, CaetanoJosiane, DragunskiDouglas Cardoso, PelláMichelly Cristina Galdioli

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

PLA/PBAT-based nanofibers containing 20% cilostazol were thinner, more crystalline, less thermally stable, and less fragile than fibers containing 30% cilostazol. Fibers containing 20% cilostazol ensured a short-term release, while those with 30% cilostazol ensured a slower release. Both types of fibers could improve the efficiency of cilostazol treatment and prevent possible side effects caused by the drug to the gastric system.
Paper Details　
Original Abstract of the Article :
Drug delivery devices are attractive alternatives to drugs usually orally administrated. Therefore, this work aimed to produce PLA/PBAT-based nanofibers for the controlled release of cilostazol, evaluating the effect of different drug concentrations (20 and 30%) over the properties of the fibers. Th...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijbiomac.2021.03.174

データ提供：米国国立医学図書館（NLM）

A New Oasis in Drug Delivery: Electrospun Nanofibers for Controlled Cilostazol Release

The desert of drug delivery research is an exciting landscape, with ongoing exploration of innovative methods for delivering medications. This study focuses on the development of electrospun poly(lactic acid) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) nanofibers for the controlled release of cilostazol. The researchers, like skilled desert artisans, crafted these nanofibers, investigating the effects of different drug concentrations on their properties. Their findings demonstrate that PLA/PBAT nanofibers can effectively control the release of cilostazol, offering a potential alternative to conventional oral administration.

A Desert Oasis of Controlled Release: A New Frontier in Drug Delivery

This research highlights the promise of electrospun nanofibers for controlled drug delivery. The study found that the nanofibers effectively released cilostazol over time, offering potential advantages in terms of improved efficacy, reduced side effects, and enhanced patient compliance. This discovery is a beacon of hope, illuminating a new frontier in drug delivery technology.

Navigating the Desert of Drug Delivery: Towards a Healthier Future

This study underscores the potential of nanotechnology to revolutionize drug delivery. By controlling the release of medications, we can potentially optimize treatment outcomes and enhance patient well-being. This research, like a well-mapped oasis, offers a promising pathway toward a healthier future, where drug delivery is more efficient, personalized, and effective.

Dr.Camel's Conclusion

The desert of drug delivery research is a vast and dynamic landscape, filled with innovative solutions. This study demonstrates the potential of electrospun nanofibers to provide a more controlled and efficient way to deliver medications. This discovery is a valuable oasis of progress, guiding us towards a future where drug delivery is tailored to individual needs, leading to better patient outcomes and a healthier world.

Date :
  1. Date Completed 2021-07-26
  2. Date Revised 2021-07-26
Further Info :

Pubmed ID

33798589

DOI: Digital Object Identifier

10.1016/j.ijbiomac.2021.03.174

Related Literature

Article Analysis
・Side Effects of cilostazol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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