Leishmanicidal effect of 1,3,4-thiadiazolium mesoionic salts on Leishmania amazonensis in vitro.

Author: AtellaGeorgia, Decote-RicardoDebora, Dos Santos RosaAlice, EchevarriaAurea, Frauches-SantosCristiane, GomesJanice S C, LimaKaroline, Pinto-da-SilvaLucia H, SantanaRaissa Couto, SaraivaElvira

Paper Details 
Original Abstract of the Article :
Leishmaniasis is a neglected broad clinical spectrum disease caused by protozoa of the genus Leishmania, which affect millions of people annually in the world and the treatment has severe side effects and resistant strains have been reported. Mesoionic salts are a subclass of the betaine group with ...See full text at original site
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引用元:
https://doi.org/10.1016/j.parint.2021.102342

データ提供:米国国立医学図書館(NLM)

Mesoionic Salts: A New Weapon Against Leishmaniasis

We're venturing into the world of neglected tropical diseases, specifically targeting leishmaniasis, a debilitating illness caused by protozoa of the genus *Leishmania*. This research explores the potential of mesoionic salts, a class of organic compounds with diverse biological activities, as a therapeutic agent for treating leishmaniasis. The researchers meticulously investigated the effects of different mesoionic salts on *Leishmania amazonensis*, a species responsible for cutaneous leishmaniasis, a form of the disease affecting the skin.

The researchers conducted a series of in vitro experiments, carefully studying the effects of mesoionic salts on the growth and survival of *L. amazonensis* parasites. They discovered that certain mesoionic salts, like skilled desert warriors, effectively targeted the parasites, inhibiting their growth and survival.

Mesoionic Salts: A Potential Therapy for Leishmaniasis

The study revealed that mesoionic salts demonstrated significant leishmanicidal activity, suggesting they could be a promising new treatment option for this neglected disease.

Mesoionic Salts: A Ray of Hope in the Desert of Leishmaniasis

This research offers hope for individuals battling the challenges of leishmaniasis. It provides evidence that mesoionic salts could be a valuable new weapon in the fight against this debilitating disease.

Dr.Camel's Conclusion

This research highlights the potential of novel therapeutic approaches for treating neglected diseases. It's a reminder that continued exploration and innovation can lead to new solutions for combating even the most challenging health problems.

Date :
  1. Date Completed 2021-09-20
  2. Date Revised 2021-09-20
Further Info :

Pubmed ID

33831578

DOI: Digital Object Identifier

10.1016/j.parint.2021.102342

Related Literature

SNS
PICO Info
in preparation
Languages

English

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