Paper Details 
Original Abstract of the Article :
The article is a short review of an observational study that proves the good efficacy and tolerability of perampanel suspension in the adjunctive treatment of epilepsy in children over 4 years of age. The study demonstrated a high level of 50% responders: 47% with focal seizures, 65% with transition...See full text at original site
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引用元:
https://doi.org/10.17116/jnevro2021121031116

データ提供:米国国立医学図書館(NLM)

Perampanel: A Promising Adjunctive Treatment for Epilepsy in Children

Epilepsy, a neurological disorder characterized by seizures, can be challenging to manage, particularly in children. This research investigates the efficacy and tolerability of perampanel suspension as an adjunctive treatment for focal and generalized tonic-clonic epileptic seizures in children over 4 years of age. The study highlights the need for effective and well-tolerated treatments for pediatric epilepsy, emphasizing the importance of minimizing potential side effects. The study's results demonstrate the efficacy of perampanel in achieving seizure control. The study found that perampanel achieved a high level of responders, with significant reductions in seizure frequency and even cessation of seizures in some patients. The study also found that perampanel was generally well-tolerated, with the most common side effects being fatigue, nasopharyngitis, lightheadedness, irritability, fever, and vomiting. Importantly, the study found no significant negative changes in cognitive function, a crucial consideration for pediatric patients.

Perampanel: A Potential Advance in Pediatric Epilepsy Treatment

This research offers hope for children with epilepsy. The study's findings suggest that perampanel can be an effective and well-tolerated adjunctive treatment option for pediatric patients. The study's focus on cognitive function is commendable, as it underscores the importance of minimizing potential cognitive side effects in children.

Health Implications and Lifestyle Considerations

The study's findings highlight the importance of early diagnosis and treatment for epilepsy. It also underscores the need for ongoing research to develop more effective and well-tolerated treatments for pediatric patients. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep, can contribute to overall health and well-being for children with epilepsy. It's crucial to consult with a healthcare professional to ensure safe and effective management.

Dr.Camel's Conclusion

Perampanel, like a shimmering oasis in a desert of seizures, offers a potential source of relief for children with epilepsy. The study's findings suggest that this medication can effectively control seizures while minimizing potential cognitive side effects. Remember, like a camel guiding its young across a challenging desert, managing epilepsy requires a tailored approach that addresses the unique needs of each child.

Date :
  1. Date Completed 2021-04-12
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

33834728

DOI: Digital Object Identifier

10.17116/jnevro2021121031116

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PICO Info
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Languages

Russian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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