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Role of eprinomectin as inhibitor of the ruminant ABCG2 transporter: Effects on plasma distribution of danofloxacin and meloxicam in sheep.

Author: AlvarezAna I, Alvarez-FernandezIndira, Blanco-PaniaguaEsther, Garcia-LinoAlba M, Garcia-MateosDafne, MedinaJuan M, MerinoGracia

Clinical Trial, VeterinaryClinical trials involving animals. They are conducted to evaluate the safety and efficacy of new drugs and treatments and contribute to the advancement of veterinary medicine.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Eprinomectin, a macrocyclic lactone used in veterinary medicine, was found to inhibit ABCG2, an efflux transporter protein involved in drug bioavailability and milk secretion. This inhibition led to increased systemic exposure of danofloxacin and meloxicam, two commonly used veterinary drugs.
Paper Details　
Original Abstract of the Article :
Therapeutic outcome results of the coadministration of several drugs in veterinary medicine is affected by, among others, the relationship between drugs and ATP-binding cassette (ABC) transporters, such as ABCG2. ABCG2 is an efflux protein involved in the bioavailability and milk secretion of drugs....See full text at original site
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引用元：
https://doi.org/10.1016/j.rvsc.2021.03.026

データ提供：米国国立医学図書館（NLM）

Eprinomectin: A Powerful Inhibitor of the ABCG2 Transporter

In the world of [veterinary medicine and drug delivery], understanding how medications are absorbed and distributed within the body is crucial for effective treatment. This research focuses on the ABCG2 transporter, a protein involved in the movement of drugs within the body, and explores the impact of eprinomectin, a commonly used veterinary drug, on its activity.

Eprinomectin: A Powerful Inhibitor of the ABCG2 Transporter

The study revealed that eprinomectin acts as a potent inhibitor of the ABCG2 transporter, blocking its ability to transport drugs out of the body. This inhibition can lead to increased systemic exposure to certain medications, like danofloxacin and meloxicam. The researchers observed that co-administering eprinomectin with these medications resulted in significantly higher plasma concentrations of both drugs, demonstrating the potential for drug-drug interactions.

Eprinomectin: A Powerful Inhibitor of the ABCG2 Transporter

This study underscores the importance of understanding drug interactions, particularly when it comes to co-administering medications. It's a reminder that seemingly unrelated drugs can have a significant impact on each other's effectiveness and safety.

Dr. Camel's Conclusion

This research reminds me of the delicate balance of the desert ecosystem, where the presence or absence of a single species can have cascading effects. Eprinomectin's inhibition of the ABCG2 transporter is like a ripple effect in the desert, demonstrating the interconnectedness of different elements within the body.

Date :
  1. Date Completed 2021-06-14
  2. Date Revised 2021-06-14
Further Info :

Pubmed ID

33838457

DOI: Digital Object Identifier

10.1016/j.rvsc.2021.03.026

Related Literature

Article Analysis
・Effects of meloxicam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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