Paper Details 
Original Abstract of the Article :
Children with acute lymphoblastic leukemia, receiving intrathecal methotrexate (IT-MTX), develop acute and subacute neurological dysfunction in 3-15% of cases. Altered level of consciousness, seizure, and stroke-like manifestations are among the most common presentations. MRI of the brain in an earl...See full text at original site
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引用元:
https://doi.org/10.29271/jcpsp.2021.04.481

データ提供:米国国立医学図書館(NLM)

Aminophylline: A Potential Solution for IT-MTX Neurotoxicity

Intrathecal methotrexate (IT-MTX) is a crucial treatment for childhood leukemia, but it can come with a significant risk of neurological complications. This research examines the potential of aminophylline, a drug used to treat asthma, as a treatment for IT-MTX-related neurotoxicity. It's like searching for a hidden spring of hope in a parched desert landscape, hoping to find a solution to a serious medical problem.

Aminophylline: A Potential Lifeline

The study finds that aminophylline infusion shows promise in treating IT-MTX-induced neurotoxicity. It's like discovering a hidden oasis, offering a potential lifeline to children struggling with this debilitating side effect of treatment. The research reveals that aminophylline can effectively reverse neurological symptoms in a significant number of cases, highlighting its potential as a valuable therapeutic tool.

Implications for Pediatric Oncology

This research could have profound implications for the care of children with leukemia. It's like paving a new path through a dangerous desert, leading to safer and more effective treatment strategies. The study's findings underscore the importance of exploring new therapeutic approaches to manage the side effects of essential cancer treatments.

Dr.Camel's Conclusion

This research is like a beacon of hope in the desert of pediatric oncology, offering a potential solution for a serious challenge. Aminophylline, a drug initially used for asthma, shows promise in treating IT-MTX neurotoxicity, potentially improving the lives of countless children battling cancer. This study reminds us that even in the most challenging medical landscapes, there is always the possibility of finding unexpected solutions.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2021-06-21
Further Info :

Pubmed ID

33866741

DOI: Digital Object Identifier

10.29271/jcpsp.2021.04.481

Related Literature

SNS
PICO Info
in preparation
Languages

English

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