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Azathioprine weekly pulse versus methotrexate for the treatment of chronic plaque psoriasis: A randomized controlled trial.

Author: BhariNeetu, GuptaSomesh, KalaivaniM, KumarPramod, VermaKaushal K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Weekly azathioprine pulse appears to be beneficial in the management of chronic plaque psoriasis but less effective than weekly methotrexate.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Methotrexate is the most commonly used drug in the treatment of psoriasis with good efficacy and safety. Recently, weekly azathioprine pulse has been shown to be effective in this disease. AIM: The aim of this study is to compare the effectiveness and safety of weekly pulse doses of aza...See full text at original site
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引用元：
https://doi.org/10.25259/IJDVL_718_18

データ提供：米国国立医学図書館（NLM）

Psoriasis Treatment: A Battle Between Azathioprine and Methotrexate

[Psoriasis] is a chronic inflammatory skin condition, and [methotrexate] is a widely used treatment. This study delves into the world of psoriasis therapy, comparing the efficacy of [weekly azathioprine pulse] to [methotrexate] for treating [chronic plaque psoriasis]. The researchers conducted a randomized controlled trial to assess the effectiveness and safety of these two drugs.

A Closer Look at Azathioprine: A Potential Alternative for Psoriasis Treatment

The study found that [weekly azathioprine pulse] was effective in treating [chronic plaque psoriasis], though less effective than [methotrexate]. While both treatments showed a significant reduction in [psoriasis severity], methotrexate demonstrated a more pronounced effect. Imagine two camels traversing the desert; both reach the oasis, but one arrives sooner and with more vigor. In the same way, both azathioprine and methotrexate can alleviate psoriasis symptoms, but methotrexate seems to be the more powerful treatment option.

Navigating the Treatment Options for Psoriasis: A Personalized Approach

This research highlights the importance of considering different treatment options for [psoriasis]. While [methotrexate] remains a primary treatment, [azathioprine] may offer an alternative for patients who cannot tolerate or have contraindications to methotrexate. Navigating the desert of psoriasis treatment requires a personalized approach, carefully considering each individual's needs and preferences.

Dr. Camel's Conclusion

This study provides valuable insights into the treatment of [chronic plaque psoriasis]. While [methotrexate] remains a strong contender, [azathioprine] offers a potential alternative for patients who cannot tolerate or have contraindications to methotrexate. This highlights the need for continued research to explore new and innovative treatments for psoriasis, providing more effective and personalized options for patients.
Date :
  1. Date Completed 2021-12-22
  2. Date Revised 2021-12-22
Further Info :

Pubmed ID

33871211

DOI: Digital Object Identifier

10.25259/IJDVL_718_18

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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