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Levoketoconazole in the Treatment of Patients With Cushing's Syndrome and Diabetes Mellitus: Results From the SONICS Phase 3 Study.

Author: ArnaldiGiorgio, CohenFredric, ElenkovaAtanaska, FeeldersRichard A, FleseriuMaria, GeerEliza B, GreenmanYona, PerottiPaola, PivonelloRosario, SaieghLeonard, WitekPrzemyslaw

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levoketoconazole effectively controlled Cushing's syndrome in patients with and without diabetes, with a higher normalization rate for patients with diabetes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Cushing's syndrome (CS) is associated with numerous comorbidities, including diabetes mellitus (DM). Levoketoconazole, an orally administered ketoconazole stereoisomer, is in clinical trials for the treatment of CS. METHODS: SONICS, a prospective, open-label, phase 3 study in adults wit...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059833/

データ提供：米国国立医学図書館（NLM）

Levoketoconazole: A New Hope for Cushing's Syndrome

This study investigates the efficacy and safety of [levoketoconazole] in treating [Cushing's syndrome (CS)] in patients with and without [diabetes mellitus (DM)]. The research utilizes a [prospective, open-label, phase 3 study] design to assess [levoketoconazole's] effects on [24-h urinary free cortisol (mUFC)] and [glycemic control]. The study found that [levoketoconazole] was effective in normalizing [mUFC] and improving [glycemic control] in patients with [CS], particularly those with [DM]. This research offers a promising new treatment option for patients with [CS], particularly those with [DM], highlighting the potential benefits of [levoketoconazole] in managing this complex condition.

Levoketoconazole: A Multifaceted Solution for Cushing's Syndrome

This research highlights the potential of [levoketoconazole] as a valuable treatment option for [Cushing's syndrome (CS)], particularly for patients with [diabetes mellitus (DM)]. The study found that [levoketoconazole] was effective in normalizing [mUFC] and improving [glycemic control], suggesting that it can address multiple aspects of this complex condition. This research could lead to improved management strategies and outcomes for patients with [CS], particularly those with [DM].

Managing Cushing's Syndrome: A Holistic Approach

This study underscores the need for a comprehensive approach to managing [Cushing's syndrome (CS)], particularly for patients with [diabetes mellitus (DM)]. The research highlights the potential benefits of [levoketoconazole] in addressing multiple aspects of this condition, including [mUFC] normalization and [glycemic control]. It's like treating the entire desert ecosystem rather than just focusing on a single sand dune, ensuring a more comprehensive and effective approach to managing the condition.

Dr.Camel's Conclusion

Just like a camel traversing the vast and often challenging desert, finding the right treatment for [Cushing's syndrome] can be a journey with many twists and turns. This research offers a promising new path with [levoketoconazole], a medication that could potentially offer a multifaceted solution for managing this complex condition. It's like finding a new oasis in the desert, providing a source of relief and hope for patients struggling with this challenging illness.
Date :
  1. Date Completed 2022-01-18
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

33897615

DOI: Digital Object Identifier

PMC8059833

Related Literature

Article Analysis
・Effects of levoketoconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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