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Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosis.
Author: BaratiSaghar, DastanFarzaneh, KobarfardFarzad, MarjaniMajid, ShahsavariNahid, TabarsiPayam, YousefianSahar
Original Abstract of the Article :
Invasive aspergillosis is a prevalent fungal disease, especially in Asian countries with a high mortality rate. Voriconazole (VRZ) is the first choice for invasive aspergillosis treatment. Plasma concentration of this drug is unpredictable and varies among individuals. This variability is influenced...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057903/
データ提供:米国国立医学図書館(NLM)
Precision Medicine in Action: Optimizing Voriconazole Therapy for Invasive Aspergillosis
Invasive aspergillosis, a serious fungal infection, poses a significant threat to individuals with weakened immune systems. This study focuses on a crucial aspect of treating this infection, exploring the importance of therapeutic drug monitoring (TDM) for voriconazole, a frontline drug used to combat invasive aspergillosis. The study investigates the variability in voriconazole plasma concentrations and its potential impact on clinical outcomes and adverse effects, emphasizing the need for individualized drug dosing to optimize treatment outcomes.
Tailoring Treatment: The Role of TDM in Optimizing Voriconazole Therapy
The study highlights the importance of TDM for voriconazole, a powerful tool that can help clinicians personalize drug dosing based on individual patient characteristics. By monitoring voriconazole plasma concentrations, clinicians can ensure that patients receive the optimal dose, maximizing the effectiveness of treatment while minimizing the risk of adverse effects. The study provides evidence that TDM is a critical component of precision medicine, enabling healthcare professionals to deliver personalized care that takes into account individual patient needs.
Optimizing Patient Outcomes: The Benefits of Precision Medicine in Aspergillosis Treatment
This study underscores the importance of TDM in managing invasive aspergillosis. By ensuring that patients receive the appropriate dose of voriconazole, healthcare professionals can improve treatment outcomes, potentially reducing the risk of treatment failure and minimizing the incidence of adverse effects. This study highlights the crucial role of precision medicine in optimizing treatment strategies for complex infections such as invasive aspergillosis, ultimately improving patient care and outcomes.
Dr.Camel's Conclusion
This study underscores the importance of therapeutic drug monitoring (TDM) in optimizing voriconazole therapy for invasive aspergillosis. By monitoring voriconazole plasma concentrations, clinicians can personalize drug dosing to maximize treatment effectiveness and minimize the risk of adverse effects, demonstrating the power of precision medicine in improving patient outcomes for complex infections. This research highlights the need for continued advancements in drug monitoring technologies to enhance precision medicine and improve patient care in various healthcare settings.
Date :
- Date Completed n.d.
- Date Revised 2022-04-22
Further Info :
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