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Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy.

Author: BesagFrank M C, VaseyMichael J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Cognitive impairments are a common concern in epilepsy, potentially caused or exacerbated by antiseizure medications (ASMs). While some ASMs may improve cognition, others can have negative effects, particularly in children. This review summarizes the evidence for cognitive changes associated with various ASMs in pediatric epilepsy patients.
Paper Details　
Original Abstract of the Article :
Impairments in cognition are common in epilepsy and may be caused or exacerbated by antiseizure medications (ASMs). Positive effects on cognition may also be seen with some ASMs. Cognitive outcomes are of particular concern in children who may be at an increased risk of cognitive adverse effects of ...See full text at original site
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引用元：
https://doi.org/10.1007/s40272-021-00448-0

データ提供：米国国立医学図書館（NLM）

Cognitive Effects of Antiseizure Medications in Children with Epilepsy

This research focuses on a vital challenge in the field of [epilepsy]. The study employed a comprehensive literature search in PubMed to explore the cognitive impacts of various antiseizure medications (ASMs) on children with epilepsy. The authors discovered that several ASMs, including phenobarbital, topiramate, and phenytoin, may lead to cognitive impairment. On the other hand, lamotrigine, levetiracetam, and fenfluramine showed potential benefits in some cognitive domains. Notably, the study highlighted the limited evidence available for many ASMs, emphasizing the need for further research in this area.

Understanding the Implications of ASM Usage in Pediatric Epilepsy

This research indicates that the use of certain ASMs can have a significant impact on cognitive development in children with epilepsy. It underscores the importance of careful monitoring and individualized treatment strategies based on the specific needs of each patient. The lack of robust data for many ASMs highlights the need for more thorough research to better understand the long-term effects of these medications on cognitive function.

Navigating the Complexities of Epilepsy Treatment

As a [doctor], I understand the importance of weighing the potential benefits and risks associated with epilepsy treatment. This study provides valuable insights into the cognitive effects of ASMs in children. It reminds us to carefully consider the individual needs of each patient and to prioritize strategies that minimize potential cognitive harm while maximizing seizure control. Understanding the nuances of these medications is crucial for making informed decisions that promote the well-being of our young patients.

Dr. Camel's Conclusion

This research sheds light on the complex relationship between antiseizure medications and cognitive development in children with epilepsy. While some medications may offer cognitive benefits, others can lead to impairment. This study highlights the need for further research and emphasizes the importance of careful consideration of each patient's individual needs when choosing treatment options.
Date :
  1. Date Completed 2021-05-28
  2. Date Revised 2021-05-28
Further Info :

Pubmed ID

33956338

DOI: Digital Object Identifier

10.1007/s40272-021-00448-0

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