Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.

Author: ChangLijia, HashimotoKenji, WeiYan

Paper Details 
Original Abstract of the Article :
The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has been a crucial breakthrough in mood disorder research. (R,S)-ketamine is a racemic mixture of equal amounts of (R)-ketamine (arketamine) and (S)-ketamine (esketamine). In...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960399/

データ提供:米国国立医学図書館(NLM)

Unveiling the Mysteries of Depression: Exploring the Antidepressant Potential of Arketamine

The pursuit of effective treatments for depression is like searching for a hidden oasis in a vast desert, a journey filled with both hope and frustration. This research explores the intriguing antidepressant properties of arketamine, a compound closely related to ketamine, and examines the potential mechanisms by which it may exert its therapeutic effects.

Beyond the Familiar: Exploring the Potential of Arketamine as an Antidepressant

The research delves into the complex mechanisms underlying the antidepressant actions of arketamine, exploring its potential to treat depression, particularly treatment-resistant depression. The researchers examine the role of the N-methyl-D-aspartate receptor (NMDAR), a key player in brain function and mood regulation, and consider alternative mechanisms that may contribute to arketamine's antidepressant effects.

A New Landscape of Possibilities: Potential Applications of Arketamine Beyond Depression

This research, like a desert traveler discovering a new path, opens up a world of possibilities for the use of arketamine. Beyond its potential for treating depression, the researchers explore its potential applications in addressing cognitive impairment, Parkinson's disease, osteoporosis, inflammatory bowel diseases, and even stroke. These potential applications, like hidden oases in the desert, offer hope for alleviating a range of debilitating conditions.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the fight against depression and other challenging conditions. The potential of arketamine, like a hidden oasis in the vast desert of mental health, offers new possibilities for treatment and relief. It's a testament to the power of scientific exploration and the relentless pursuit of solutions for human suffering.

Date :
  1. Date Completed 2022-04-11
  2. Date Revised 2023-02-01
Further Info :

Pubmed ID

33963284

DOI: Digital Object Identifier

PMC8960399

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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