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Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Author: GuydoshNicholas R, KlepackiDorota, KollerTimm O, MankinAlexander S, MeydanSezen, PolacekNorbert, ShankarVaishnavi, SvetlovMaxim S, Vázquez-LaslopNora, WilsonDaniel N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Macrolides are antibiotics that inhibit bacterial protein synthesis by binding to the ribosome. This study investigated whether macrolides could be used to inhibit specific protein synthesis in eukaryotic cells. By introducing a single mutation in rRNA, the researchers rendered yeast cells sensitive to macrolides. They found that the drug telithromycin binds to the eukaryotic ribosome and inhibits translation in a context-specific manner. This suggests that macrolides could potentially be used for protein-selective translation inhibition in eukaryotic cells.
Paper Details　
Original Abstract of the Article :
Macrolide antibiotics bind in the nascent peptide exit tunnel of the bacterial ribosome and prevent polymerization of specific amino acid sequences, selectively inhibiting translation of a subset of proteins. Because preventing translation of individual proteins could be beneficial for the treatment...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121947/

データ提供：米国国立医学図書館（NLM）

Macrolide Antibiotics: A New Frontier in Protein-Specific Translation Inhibition

This study explores the intriguing world of macrolide antibiotics, investigating their ability to selectively inhibit protein translation in eukaryotic cells. The research delves into the molecular mechanisms underlying the action of macrolides and explores their potential for targeted protein manipulation.

A Tale of Two Ribosomes: Understanding Macrolide Specificity

The researchers discovered that macrolides, when bound to the eukaryotic ribosome, can selectively inhibit the translation of specific proteins, depending on the amino acid sequence. This finding opens exciting possibilities for using macrolides to precisely control protein production in eukaryotic cells.

The Future of Therapeutics: Harnessing the Power of Macrolides

This research suggests that macrolides could be adapted for targeted protein inhibition in eukaryotic cells, offering a novel approach to treating a wide range of human diseases. The study highlights the potential of these antibiotics as a powerful tool for manipulating protein expression and developing new therapeutic strategies.

Dr.Camel's Conclusion

Imagine a desert where the sands of protein translation shift and change. This study, like a desert wind, unveils the potential of macrolide antibiotics to selectively manipulate this process, paving the way for a new era of targeted therapeutic interventions. The research offers a glimpse into the future of medicine, where we can precisely control protein production to combat disease and improve human health.

Date :
  1. Date Completed 2021-06-03
  2. Date Revised 2021-06-03
Further Info :

Pubmed ID

33990576

DOI: Digital Object Identifier

PMC8121947

Related Literature

Article Analysis
・Effects of telithromycin
SNS
PICO Info
in preparation
Languages

English

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