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Emulgel for improved topical delivery of Tretinoin: Formulation design and characterization.

Author: DisouzaJ, DwivediJ, KumbharP, MalaviS, ManjappaA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed and optimized a tretinoin (TRT)-loaded topical emulgel formulation. The optimized formulation displayed controlled TRT release and good stability. It showed promising anti-acne activity in vitro and in vivo, with no signs of irritation.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The chief objective of the present research was to reduce local side effects by reducing the dose, controlling the release, and improving the stability by developing and optimizing tretinoin (TRT)-loaded topical emulgel formulation. METHODS: TRT emulgel (TE) was prepared and optimized a...See full text at original site
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引用元：
https://doi.org/10.1016/j.pharma.2021.05.004

データ提供：米国国立医学図書館（NLM）

Improving Tretinoin Delivery: A New Emulgel Formulation

This research focuses on optimizing the delivery of tretinoin, a widely used topical medication for acne treatment. The researchers developed and characterized a novel emulgel formulation of tretinoin, aiming to improve its efficacy and reduce potential side effects. The study found that the emulgel formulation effectively controlled the release of tretinoin, demonstrating comparable anti-acne activity to a marketed product. This research offers a promising approach for improving the topical delivery of tretinoin, potentially enhancing treatment outcomes and minimizing side effects. The study also highlights the importance of formulation design and characterization in optimizing drug delivery systems.

Improving Drug Delivery: A Focus on Formulation

This research showcases the importance of formulation design and characterization in optimizing drug delivery systems. The study highlights the effectiveness of a novel emulgel formulation for tretinoin, demonstrating controlled release and comparable anti-acne activity to a marketed product. It's like discovering a new pathway through the vast desert of drug delivery, leading to more efficient and effective therapeutic outcomes.

Treating Acne: A Focus on Topical Treatments

Acne is a common skin condition that can significantly impact self-esteem. This research highlights the potential benefits of a novel emulgel formulation for tretinoin, offering a promising approach for improving the topical delivery of this widely used acne treatment. It's like finding a hidden oasis of effective treatment options in the vast desert of acne solutions, offering a more convenient and potentially less irritating approach to managing this common skin condition.

Dr. Camel's Conclusion

This research explores the optimization of tretinoin delivery through a novel emulgel formulation. The study demonstrates improved drug release, comparable anti-acne activity to a marketed product, and reduced potential side effects. It's like discovering a new path through the vast desert of acne treatment options, leading to a more effective and well-tolerated approach for managing this common skin condition.
Date :
  1. Date Completed 2022-02-23
  2. Date Revised 2022-02-23
Further Info :

Pubmed ID

34029557

DOI: Digital Object Identifier

10.1016/j.pharma.2021.05.004

Related Literature

Article Analysis
・Side Effects of tretinoin
SNS
PICO Info
in preparation
Languages

English

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