Case report: asenapine and anticholinergic toxicity.

Author: HawaRaed J, RasimasJoseph J, Richards-BentleyChristopher, SheehanAnn Kathleen

Paper Details 
Original Abstract of the Article :
While antipsychotic medications have long been associated with anticholinergic effects, asenapine has been purported to have no capacity for muscarinic cholinergic antagonism based on in vitro studies. Research in rat brain tissue has yielded different results, with one study finding more cholinergi...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/34030165

データ提供:米国国立医学図書館(NLM)

A New Twist on Anticholinergic Toxicity

This research delves into the complex world of antipsychotic medications and their potential side effects. It's like exploring a hidden oasis in the desert, uncovering unexpected properties of a seemingly familiar plant. The study focuses on asenapine, an antipsychotic medication that was initially believed to have no anticholinergic effects. However, this case report presents evidence suggesting that asenapine might indeed have anticholinergic potential, leading to a possible anticholinergic toxidrome. This is like discovering a desert plant that appears harmless but can produce unexpected and harmful effects when ingested.

The Results: Asenapine's Unexpected Side Effects

The study describes a case of a patient experiencing an anticholinergic toxidrome after an upward titration of asenapine. This is like discovering a desert plant that, when consumed in increasing amounts, can lead to dangerous side effects. The patient's symptoms, which resembled anticholinergic poisoning, were initially attributed to other medications, but the time course and clinical features pointed to asenapine as the culprit. This highlights the importance of considering all potential side effects of medications, even those that are not well-established.

Impact on Medication Safety: Being Aware of Unexpected Side Effects

This study underscores the importance of being cautious with medications and considering all possible side effects. It's like remembering that even the most familiar desert plant can harbor hidden dangers. The study suggests that asenapine should be added to the list of antipsychotics with potential anticholinergic effects. This can help clinicians better understand the risks and benefits of asenapine and make informed decisions about its use.

Dr. Camel's Conclusion

This case report reminds us that the desert of medication can be deceptive. What appears to be a harmless plant could be a source of danger. The study highlights the importance of being aware of all potential side effects of medications, even those that are not widely known. It's a reminder that even in the vast desert of medical knowledge, there are always new things to learn and new dangers to watch out for.

Date :
  1. Date Completed 2021-12-23
  2. Date Revised 2022-11-09
Further Info :

Pubmed ID

34030165

DOI: Digital Object Identifier

00004850-202107000-00007

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Languages

English

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