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Pitolisant in an Adolescent with Prader-Willi Syndrome.

Author: PenningtonStephanie, SannarElise, StutzmanDanielle

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report explores the potential benefits of pitolisant in a 15-year-old female with Prader-Willi syndrome, obsessive-compulsive disorder, autism spectrum disorder, and mild intellectual disability. The drug appears to be well-tolerated with minimal side effects.
Paper Details　
Original Abstract of the Article :
This case report evaluates the potential benefit of pitolisant in a 15-year-old female with Prader-Willi syndrome, obsessive-compulsive disorder, autism spectrum disorder, and mild intellectual disability. Due to its action on the H3 receptor, it enhances central activity of histaminergic neurons re...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139568/

データ提供：米国国立医学図書館（NLM）

Pitolisant for Prader-Willi Syndrome: A Promising Treatment

Prader-Willi syndrome is a rare genetic disorder that can lead to a range of challenges, including excessive hunger, obesity, and developmental delays. This study examines the potential benefits of a medication called pitolisant for treating symptoms in a 15-year-old girl with Prader-Willi syndrome, obsessive-compulsive disorder, autism spectrum disorder, and mild intellectual disability.

Pitolisant's Mechanism of Action

Pitolisant works by activating histaminergic neurons, which are involved in alertness and other brain functions. It is thought to improve symptoms of Prader-Willi syndrome by modulating various neurotransmitter systems, including acetylcholine, norepinephrine, and dopamine.

Potential Benefits and Tolerability

The results of this case report suggest that pitolisant may be a promising treatment option for patients with Prader-Willi syndrome. The patient in this study tolerated pitolisant well, with minimal side effects.

Dr.Camel's Conclusion

This research, like a single oasis in the vast desert of Prader-Willi syndrome, offers a glimmer of hope for patients struggling with the challenges of this disorder. While more research is needed to confirm its efficacy and safety, pitolisant may provide a new avenue for addressing the multifaceted symptoms of Prader-Willi syndrome.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-05-28
Further Info :

Pubmed ID

34035686

DOI: Digital Object Identifier

PMC8139568

Related Literature

Article Analysis
・Side Effects of pitolisant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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