The Analgesic Benefits of Ketorolac to Local Anesthetic Wound Infiltration Is Statistically Significant But Clinically Unimportant: A Comprehensive Systematic Review and Meta-Analysis.

The Analgesic Benefits of Ketorolac-Infiltration: A Systematic Review and Meta-Analysis

Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), is often used as an adjuvant to local anesthetics for wound infiltration in surgical procedures. This study systematically reviewed and meta-analyzed published randomized controlled trials (RCTs) to evaluate the efficacy and safety of ketorolac-infiltration for postoperative pain management. The researchers aimed to provide a comprehensive assessment of the evidence base for this practice and to determine its clinical significance.

Limited Clinical Significance of Ketorolac-Infiltration for Postoperative Pain

The meta-analysis revealed that ketorolac-infiltration provided a statistically significant but clinically unimportant benefit in reducing morphine consumption and wound pain at rest. While ketorolac-infiltration was associated with shorter hospital stays, this effect was attributed to factors other than pain relief. Furthermore, ketorolac-infiltration did not improve opioid-related side effects.

Optimizing Postoperative Pain Management Strategies

This research suggests that ketorolac-infiltration provides limited clinical benefits for postoperative pain management. It emphasizes the need for optimizing anesthetic agents and delivery methods to improve pain control after surgery.

Dr.Camel's Conclusion

This research is like a camel caravan searching for the most effective pain relief strategies in the vast desert of postoperative care. The study explores the role of ketorolac-infiltration, a common practice in surgery. It’s like finding a hidden oasis in the desert – a reminder that while we may have established practices, there might be better approaches waiting to be discovered.