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A general prodrug nanohydrogel platform for reduction-triggered drug activation and treatment of taxane-resistant malignancies.

Author: FangShijiang, LiTongyu, ShiXiaowei, WangHangxiang, WangYuchen, YaoJie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new nanohydrogel platform for drug delivery releases anticancer agents like cabazitaxel in response to the reducing environment of tumors, showing promising results in a preclinical model and a higher safety profile than free drug solutions.
Paper Details　
Original Abstract of the Article :
Chemotherapy has been widely used for treating the vast majority of cancer patients. Unfortunately, only a fraction of patients can respond to chemotherapies, but these patients still experience severe side effects. In this context, a wide range of nanotherapeutic platforms have been developed with ...See full text at original site
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引用元：
https://doi.org/10.1016/j.actbio.2021.05.047

データ提供：米国国立医学図書館（NLM）

Nanohydrogels: A Smart Delivery System for Targeted Cancer Therapy

Chemotherapy, while a valuable tool in the fight against cancer, often comes with significant side effects. This research explores the potential of nanohydrogels as a smart delivery system for chemotherapy drugs, specifically targeting the reducing tumor microenvironment. The researchers developed a prodrug hydrogel platform that releases active agents, like the cytotoxic drug cabazitaxel, only in response to the reducing conditions found within the tumor. This targeted drug release strategy promises to enhance the effectiveness of chemotherapy while minimizing side effects. It's like guiding a caravan through a treacherous desert, ensuring that supplies are delivered only where they are needed most.

Nanohydrogels: A New Frontier in Cancer Treatment

This research highlights the potential of nanohydrogels as a smart delivery system for chemotherapy drugs. The targeted drug release strategy could lead to more effective cancer treatments with fewer side effects.

Precision Medicine: A Personalized Approach to Cancer Care

This research underscores the importance of precision medicine, tailoring treatments to the specific characteristics of each patient and tumor. By targeting the reducing tumor microenvironment, this nanohydrogel platform offers a more personalized approach to cancer therapy.

Dr. Camel's Conclusion

The fight against cancer requires innovative solutions, and nanohydrogels offer a promising avenue. This research showcases the potential of a smart delivery system that targets the reducing tumor microenvironment, leading to more effective treatments with fewer side effects. It’s like discovering a hidden oasis in the desert, offering a haven of hope and healing for those struggling with cancer. Let's continue to explore the vast landscape of cancer research, driven by a commitment to finding better treatments and improving the lives of those affected by this disease.

Date :
  1. Date Completed 2021-08-02
  2. Date Revised 2021-08-02
Further Info :

Pubmed ID

34087447

DOI: Digital Object Identifier

10.1016/j.actbio.2021.05.047

SNS
PICO Info
in preparation
Languages

English

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